Regeneration of Human Intrabony Defects With rhFGF-2/HA
Periodontitis

About this trial
This is an interventional treatment trial for Periodontitis focused on measuring alveolar bone loss, periodontal attachment loss
Eligibility Criteria
Inclusion Criteria:
(a) adult subjects with chronic periodontitis presenting (b) radiographic evidence alveolar bone loss at the proximal aspect of the tooth, (c) intrabony defect deeper than 4mm, (d) probing pocket depth >6 mm at the site, (e) unremarkable general health according to medical history and clinical judgment, (f) no medications taken for at least six months and no antibiotics taken for twelve months before the beginning of the study.
Exclusion Criteria:
(a) subjects with "early onset" or aggressive forms of periodontitis, (b) current smokers, (c) presence of significant systemic diseases (i.e., cancer, AIDS, diabetes), (d) clinical evidence of furcation defects, (e) presence of apical radioleucency and (f) previous lack of cooperation with the maintenance program.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Control
Test
open instrumentation of the root surfaces and bone defects via flap modified papilla preservation flap
open instrumentation of the root surfaces and bone defects via flap modified papilla preservation flap and application of a rhFGF-2/HA in the intrabony defect