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Cognitive Training in Inpatient Treatment for Substance Use Disorders

Primary Purpose

Substance Use Disorders

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Cognitive training activities
Inpatient psychosocial therapy
Sponsored by
Centre for Addiction and Mental Health
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Substance Use Disorders

Eligibility Criteria

18 Years - 60 Years (Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health
  • Age 18-60
  • Fluency in English
  • Able to attend scheduled training sessions
  • Comfortable using a computer and mouse

Exclusion Criteria:

  • Severe cognitive impairment
  • Current or past psychosis or diagnosis of schizophrenia
  • Photosensitive epilepsy or history of seizures triggered by light
  • Legal mandate to attend treatment

Sites / Locations

  • Centre for Addiction and Mental Health

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Experimental

Control

Arm Description

Computerized cognitive training activities

Non-adaptive computerized cognitive training activities

Outcomes

Primary Outcome Measures

Auditory memory capacity - WAIS Digit Span score
WAIS Digit Span score

Secondary Outcome Measures

Auditory memory capacity - WAIS Letter-number sequencing score
WAIS Letter-number sequencing score
Visual memory capacity - WMS Spatial span score
WMS Spatial span score
Visual memory capacity - WMS Symbol span score
WMS Symbol span score
Training progress score - Cognitive progress indicator score
Cognitive progress indicator score

Full Information

First Posted
February 2, 2015
Last Updated
July 25, 2016
Sponsor
Centre for Addiction and Mental Health
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1. Study Identification

Unique Protocol Identification Number
NCT02356718
Brief Title
Cognitive Training in Inpatient Treatment for Substance Use Disorders
Official Title
Cognitive Training in Inpatient Treatment for Substance Use Disorders
Study Type
Interventional

2. Study Status

Record Verification Date
July 2016
Overall Recruitment Status
Completed
Study Start Date
January 2015 (undefined)
Primary Completion Date
July 2016 (Actual)
Study Completion Date
July 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Centre for Addiction and Mental Health

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders.
Detailed Description
Participants will complete cognitive training sessions on a regular basis during inpatient treatment. Alternate versions of the computer tasks will be compared in a randomized design. Primary and secondary outcomes will consist of changes in cognitive performance before and after the training period.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Substance Use Disorders

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantOutcomes Assessor
Allocation
Randomized
Enrollment
111 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Experimental
Arm Type
Experimental
Arm Description
Computerized cognitive training activities
Arm Title
Control
Arm Type
Active Comparator
Arm Description
Non-adaptive computerized cognitive training activities
Intervention Type
Behavioral
Intervention Name(s)
Cognitive training activities
Intervention Description
Training activities consist of computer tasks designed to improve memory and cognition. The intervention consists of 45-minute training sessions delivered regularly during inpatient treatment.
Intervention Type
Behavioral
Intervention Name(s)
Inpatient psychosocial therapy
Intervention Description
Group psychosocial therapy delivered in an inpatient setting.
Primary Outcome Measure Information:
Title
Auditory memory capacity - WAIS Digit Span score
Description
WAIS Digit Span score
Time Frame
Baseline, 3 weeks
Secondary Outcome Measure Information:
Title
Auditory memory capacity - WAIS Letter-number sequencing score
Description
WAIS Letter-number sequencing score
Time Frame
Baseline to 3 weeks
Title
Visual memory capacity - WMS Spatial span score
Description
WMS Spatial span score
Time Frame
Baseline to 3 weeks
Title
Visual memory capacity - WMS Symbol span score
Description
WMS Symbol span score
Time Frame
Baseline to 3 weeks
Title
Training progress score - Cognitive progress indicator score
Description
Cognitive progress indicator score
Time Frame
Baseline to 4 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health Age 18-60 Fluency in English Able to attend scheduled training sessions Comfortable using a computer and mouse Exclusion Criteria: Severe cognitive impairment Current or past psychosis or diagnosis of schizophrenia Photosensitive epilepsy or history of seizures triggered by light Legal mandate to attend treatment
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christian Hendershot, PhD
Organizational Affiliation
Centre for Addiction and Mental Health
Official's Role
Principal Investigator
Facility Information:
Facility Name
Centre for Addiction and Mental Health
City
Toronto
State/Province
Ontario
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
30475014
Citation
Hendershot CS, Wardell JD, Vandervoort J, McPhee MD, Keough MT, Quilty LC. Randomized trial of working memory training as an adjunct to inpatient substance use disorder treatment. Psychol Addict Behav. 2018 Dec;32(8):861-872. doi: 10.1037/adb0000415. Epub 2018 Nov 26.
Results Reference
derived
Links:
URL
http://www.camh.ca/en/research
Description
The Centre for Addiction and Mental Health (CAMH) is the leading mental health and addictions research facility in Canada, and one of the largest in the world.

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Cognitive Training in Inpatient Treatment for Substance Use Disorders

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