Wound Dressings for Pemphigus and Pemphigoid
Pemphigus, Pemphigoid
About this trial
This is an interventional treatment trial for Pemphigus focused on measuring Pemphigus, Pemphigoid, Wound Healing, Itch, Pain, Wound dressing, Topical treatment
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of pemphigus vulgaris, pemphigus foliaceus , pemphigus vegetans, paraneoplastic pemphigus or bullous pemphigoid
- At least four areas of active disease in the trunk or limbs of 8 x 8 cm characterized by denudation, ulceration, scabs or blisters.
- Capable of being evaluated weekly either as outpatient or hospitalized
- Actively treated with immunosuppressive or immunomodulatory drugs for pemphigus or pemphigoid control
- Willing to sign an informed consent
Exclusion Criteria:
- Patients with hypersensitivity to any of the components of the skin dressings that will be used.
- Patients who have participated in any clinical trial in the last 30 days.
Sites / Locations
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRecruiting
- Hospital General Dr Manuel Gea GonzálezRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Cotton gauze with petrolatum
Cellulose acetate with petrolatum
Nanocrystalline silver
Carboxymethylcellulose with ionic silver
The dressing to be used is regular cotton gauze impregnated in petrolatum (a mixture of solid hydrocarbons) creating a film that reduces the adherence of the gauze to the wound.
The dressing to be used is a mesh or tulle base of cellulose acetate polymers that do not easily adhere to the wound impregnated in petrolatum (a mixture of solid hydrocarbons).
The dressing to be used consists of two layers of a silver-coated, high-density polyethylene mesh, enclosing a single layer of an apertured non-woven fabric of rayon and polyester. The three components are ultrasonically welded together to maintain the integrity of the dressing in use. Silver is applied to the polyethylene mesh by a vapour deposition process, which results in the formation of microscopic 'nanocrystals' of metallic silver.
The dressing to be used is a soft, sterile, non- woven pad dressing made from sodium carboxymethylcellulose containing 1.2% silver in an ionic form.