Cough According to Stimulus Type in PD
Parkinson's Disease
About this trial
This is an interventional diagnostic trial for Parkinson's Disease focused on measuring Dysphagia, Cough, Aspiration pneumonia
Eligibility Criteria
Inclusion Criteria:
- Within age limits
- For PD group: confirmed diagnosis of idiopathic parkinson's disease
Exclusion Criteria:
- Uncontrolled hypertension
- Difficulty complying due to neuropsychological dysfunction (i.e., severe depression)
- Allergy to capsaicin or hot peppers
- History of head or neck cancer
Neurological disorders other than PD (i.e., stroke, etc.)
1. control participants only: any history of neurologic disorders including PD
- History of smoking in the last 5 years
- Breathing disorders or diseases
Sites / Locations
- University of Florida Center for Movement Disorders and Neurorestoration
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Healthy control
Parkinson's disease - no PA
Parkinson's disease - PA
Healthy age-matched adult participants with no history of Parkinson's disease Participants in this group will receive capsaicin vapor cough provocation test. The vapor will be delivered using a small hand-held nebulizer.
People with Parkinson's disease without penetration or aspiration during swallowing; based on results of videofluoroscopic swallow evaluation. Participants in this group will receive capsaicin vapor and fog cough provocation test using a small, hand-held nebulizer.Participants in the group will also receive a fluoroscopic swallow evaluation.
People with Parkinson's disease with penetration or aspiration during swallowing;based on results of videofluoroscopic swallow evaluation.Participants in this group will receive capsaicin vapor and fog cough provocation test using a small, hand-held nebulizer. Participants in the group will also receive a fluoroscopic swallow evaluation.