Cognitive-Based Compassion Training (CBCT) for People Living With HIV (PLHIV)
Human Immunodeficiency Virus
About this trial
This is an interventional supportive care trial for Human Immunodeficiency Virus focused on measuring Cognitive-Based Compassion Training (CBCT), HIV-related clinical outcomes, Stress and stress-related psychological adjustment, Stress-related inflammatory biomarkers
Eligibility Criteria
Inclusion Criteria:
Subjects living with HIV-1 infection who have been on continuous ART for a minimum of 12 months and:
- are followed longitudinally for their HIV healthcare at the Infectious Disease Program
- meet criteria for immunological non-responsiveness as defined by adherence to ART and cluster of differentiation 4 (CD4) count <350 cells/μL despite complete virologic suppression (> 2 plasma HIV viral load (pVL) below the limit of detection including the most recent pVL prior to enrollment).
- Ability to give informed consent.
- Score at least 1 standard deviation above socioeconomic status (SES)-matched general population norms on Perceived Stress Scale (PSS)
Exclusion Criteria:
- History of psychosis
- HIV-related neurocognitive decline
- Substance abuse within the last year
- Documented history of cirrhosis or a total bilirubin ≥ 2.0 mg/dL
- Known or possible pregnancy or attempting to become pregnant
- BMI below 17 or above 30
- Age < 18
- Bipolar disorder
- Bleeding disorders such as thrombocytopenia or significant gastrointestinal bleeding within the past year
- Continuous ART for < 12 months
Sites / Locations
- Grady Hospital - Ponce De Leon Clinic
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Cognitive-Based Compassion Training (CBCT)
Health Discussion Control
HIV-1 positive subjects on antiretroviral therapy (ART) will be randomized to receive an 8-week program of Cognitive-Based Compassion Training (CBCT).
HIV-1 positive subjects on antiretroviral therapy (ART) will be randomized to attend a health discussion group for 8 weeks.