Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring tissue expander, breast reconstruction
Eligibility Criteria
Inclusion Criteria:
- females between 18 - 81 years of age
- and are undergoing bilateral mastectomy
- and are candidates for immediate breast reconstruction with tissue expanders.
Exclusion Criteria:
- females younger than 18 and older than 81 years of age;
- undergoing unilateral mastectomy and reconstruction;
- bilateral reconstruction using other techniques,
- patients allergic to one or more components of the antibiotic solution;
- allergy to CHG
Sites / Locations
- Vanderbilt University Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Chlorhexidine irrigation
triple antibiotic irrigation
0.05% chlorhexidine solution (IrriSept®) commercially prepared in 450 ml bottles for irrigation. Each patient will receive triple antibiotic solution on one breast and the CHG on the other breast.
triple antibiotic solution will contain 1 g of cefazolin, 50,000 U of bacitracin, and 80 mg of gentamicin in 500 mL of normal saline (NS). If the patient is allergic to either component - the allergen will not be used in the solution - for irrigation. Each patient will receive triple antibiotic solution on one breast and the CHG on the other breast.