Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol (FAVOR)
Primary Purpose
Blood Pressure, Ischemic Stroke
Status
Unknown status
Phase
Phase 4
Locations
Study Type
Interventional
Intervention
Fimasartan
Valsartan
Atenolol
Sponsored by
About this trial
This is an interventional treatment trial for Blood Pressure
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 30 years old
- Acute ischemic stroke patient who has corresponding DWI(diffusion- weighted imaging) lesion correlated with symptom
- after 7days, but within 28days from stroke onset
- Diagnosed with Hypertension
- hypertensive patients who taking anti-hypertensive drugs or SBP≥140mmHg
- Informed consent
Exclusion Criteria:
- Patients with hemorrhagic Stroke
- Patients with severe Stroke - over NIHss(National Institutes of Health stroke scale) 16
- Uncontrolled hypertension (SBP ≥200mmHg)
- Patients with history of allergic reaction to any angiotensin II antagonist
- Liver disease(more than double to normal level, SGOT(serum glutamic-oxaloacetic transaminase ), SGPT(serum glutamic-pyruvic transaminase ), total bilirubin)
- Renal disease(serum creatinine ≥2.0mg/dl)
- Anemia(Hb < 8mg/dl)
- Thrombocytopenia( < 10^3/ml)
- Patients with secondary hypertension
- Childbearing and breast-feeding women
- Otherwise inappropriate patients depending on the investigator's decision
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Active Comparator
Active Comparator
Arm Label
Fimasartan
Valsartan
Atenolol
Arm Description
fimasartan potassium 60mg, 1 tablet by mouth, every day Angiotensin ll receptor blocker
valsartan 80mg, 1 tablet by mouth, every day angiotensin II receptor antagonists
atenolol 50mg, 1 tablet by mouth, every day beta-blocker
Outcomes
Primary Outcome Measures
Central Blood pressure control
Secondary Outcome Measures
Blood pressure at the brachial artery
Brachial-ankle pulse wave velocity (ba-PWV)
Ba-PWV is measured using ABI/PWV (VP-2000; Colin). This device has four cuffs that can be used to simultaneously measure blood pressure in both arms and both legs, and automatically calculate the ABI. It also records pulse waves with the sensors in the cuffs, computes the difference between transmission time in the arm and transmission time in the ankle, calculates the transmission distance from the right arm to each ankle according to body height, and thus computes the ba-PWV values from the transmission time and transmission distance.
Flow-mediated dilation (FMD)
FMD is measured as the brachial artery diameters at baseline and at maximum dilation after forearm ischemia for 5 minutes. FMD is calculated as the percentage of postischemic dilation.
Pulsatile index (PI)
We analyze the change of PIs in the middle cerebral artery at baseline and 90 Days on transcranial Doppler (TCD) Study in the same patient. The PI is automatically calculated on the TCD machine (PMD 150, Sphencer technologies, USA).
Cerebral blood flow (CBF) volume
CBF volume is measured by color-coded duplex sonography measuring total flow volumes of the internal carotid artery (ICAs) and vertebral artery (VAs).
Adverse Events
Full Information
NCT ID
NCT02403349
First Posted
March 12, 2015
Last Updated
March 26, 2015
Sponsor
Ajou University School of Medicine
Collaborators
Boryung Pharmaceutical Co., Ltd
1. Study Identification
Unique Protocol Identification Number
NCT02403349
Brief Title
Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol
Acronym
FAVOR
Official Title
Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol
Study Type
Interventional
2. Study Status
Record Verification Date
March 2015
Overall Recruitment Status
Unknown status
Study Start Date
May 2012 (undefined)
Primary Completion Date
May 2015 (Anticipated)
Study Completion Date
September 2015 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Ajou University School of Medicine
Collaborators
Boryung Pharmaceutical Co., Ltd
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Confirm central blood pressure reduction effect of Fimasartan, Valsartan and Atenolol and compare correlation with the measured peripheral (central blood pressure, pulse wave velocity, and flow-mediated dilation) and cerebral blood flow factors (transcranial doppler findings, cerebral blood flow volume) in acute ischemic stroke patients with hypertension.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Blood Pressure, Ischemic Stroke
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
105 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Fimasartan
Arm Type
Experimental
Arm Description
fimasartan potassium 60mg, 1 tablet by mouth, every day Angiotensin ll receptor blocker
Arm Title
Valsartan
Arm Type
Active Comparator
Arm Description
valsartan 80mg, 1 tablet by mouth, every day angiotensin II receptor antagonists
Arm Title
Atenolol
Arm Type
Active Comparator
Arm Description
atenolol 50mg, 1 tablet by mouth, every day beta-blocker
Intervention Type
Drug
Intervention Name(s)
Fimasartan
Other Intervention Name(s)
kanarb
Intervention Type
Drug
Intervention Name(s)
Valsartan
Other Intervention Name(s)
Diovan
Intervention Type
Drug
Intervention Name(s)
Atenolol
Other Intervention Name(s)
tenormin
Primary Outcome Measure Information:
Title
Central Blood pressure control
Time Frame
12 weeks
Secondary Outcome Measure Information:
Title
Blood pressure at the brachial artery
Time Frame
12 weeks
Title
Brachial-ankle pulse wave velocity (ba-PWV)
Description
Ba-PWV is measured using ABI/PWV (VP-2000; Colin). This device has four cuffs that can be used to simultaneously measure blood pressure in both arms and both legs, and automatically calculate the ABI. It also records pulse waves with the sensors in the cuffs, computes the difference between transmission time in the arm and transmission time in the ankle, calculates the transmission distance from the right arm to each ankle according to body height, and thus computes the ba-PWV values from the transmission time and transmission distance.
Time Frame
12 weeks
Title
Flow-mediated dilation (FMD)
Description
FMD is measured as the brachial artery diameters at baseline and at maximum dilation after forearm ischemia for 5 minutes. FMD is calculated as the percentage of postischemic dilation.
Time Frame
12 weeks
Title
Pulsatile index (PI)
Description
We analyze the change of PIs in the middle cerebral artery at baseline and 90 Days on transcranial Doppler (TCD) Study in the same patient. The PI is automatically calculated on the TCD machine (PMD 150, Sphencer technologies, USA).
Time Frame
12 weeks
Title
Cerebral blood flow (CBF) volume
Description
CBF volume is measured by color-coded duplex sonography measuring total flow volumes of the internal carotid artery (ICAs) and vertebral artery (VAs).
Time Frame
12 weeks
Title
Adverse Events
Time Frame
12 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Age ≥ 30 years old
Acute ischemic stroke patient who has corresponding DWI(diffusion- weighted imaging) lesion correlated with symptom
after 7days, but within 28days from stroke onset
Diagnosed with Hypertension
hypertensive patients who taking anti-hypertensive drugs or SBP≥140mmHg
Informed consent
Exclusion Criteria:
Patients with hemorrhagic Stroke
Patients with severe Stroke - over NIHss(National Institutes of Health stroke scale) 16
Uncontrolled hypertension (SBP ≥200mmHg)
Patients with history of allergic reaction to any angiotensin II antagonist
Liver disease(more than double to normal level, SGOT(serum glutamic-oxaloacetic transaminase ), SGPT(serum glutamic-pyruvic transaminase ), total bilirubin)
Renal disease(serum creatinine ≥2.0mg/dl)
Anemia(Hb < 8mg/dl)
Thrombocytopenia( < 10^3/ml)
Patients with secondary hypertension
Childbearing and breast-feeding women
Otherwise inappropriate patients depending on the investigator's decision
12. IPD Sharing Statement
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Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol
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