Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function
Vestibular Schwannoma
About this trial
This is an interventional prevention trial for Vestibular Schwannoma focused on measuring Vestibular schwannoma, acoustic neuroma, cerebellopontine angle tumour, gentamicin, rehabilitation, postural balance
Eligibility Criteria
Inclusion Criteria:
- Vestibular schwannoma advised to surgical treatment
- No measurable remaining vestibular function
Exclusion Criteria:
- impaired decision making
- neurofibromatosis
- signs for central dysfunction
- remaining vestibular function
- Patients are advised not to participate in the gentamicin arm if
- hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz) and speech discrimination better than 70%
- the neurosurgeon aim at hearing preservation surgery and do not want to risk gentamicin associated hearing loss
Sites / Locations
- Dept. OtoRhinoLaryngology Head and Neck Surgery, Skane University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Gentamicin treated
Non-gentamicin
Installation of gentamicin in the middle ear 6 weeks prior to surgery + rehabilitation exercises before and after both treatment and surgery. Rehabilitation exercises are not considered to be an intervention since their benign impact on vestibular/postural compensation is well documented and exclusion from exercises would not be approved by the ethical board
Rehabilitation exercises before and after both treatment and surgery Rehabilitation exercises are not considered to be an intervention since their benign impact on vestibular/postural compensation is well documented and exclusion from exercises would not be approved by the ethical board