Strategy of Transfusion in Trauma Patients - STATA Trial (STATA)
Wounds and Injuries
About this trial
This is an interventional treatment trial for Wounds and Injuries focused on measuring Thrombelastography, Massive Transfusion, Major Trauma, Blood products, Thromboelastometry
Eligibility Criteria
Inclusion Criteria:
- Trauma victims
- Adults between 18 - 80 years old
- Injury Severity Score (ISS) between 15 and 45
- Assessment of Blood Consumption (ABC) Score ≥ 3 points
- Shock Index ≥ 1,2
Exclusion Criteria:
- Early cardiac arrest
- Pregnancy
- ISS > 45
- Patient transferred from another hospital
- Drug abuse history
- Known coagulation impairment
- Known use of anticoagulants, or platelet anti-aggregants. -
Sites / Locations
- Hospital das Clínicas FMUSP
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Blood Products only.
Point of care guided
This arm will receive 1:1:1 Red blood cells : Fresh Frozen Plasma : Platelets upon a major trauma triggers. 1:1:1 Ratio for packs of blood products. The patient will be re-evaluated every hour again for the major bleeding triggers and another 1:1:1 intervention may or may not occur.
This arm will receive Red blood cells, Human Fibrinogen and Prothrombinic complex concentrates (PCC) based on thromboelastometry. The dosis of each drug will be determined by the analyses of the thromboelastometry curves.