2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
Primary Purpose
Duchenne Muscular Dystrophy
Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
speckle tracking (2D strain) echocardiography
Sponsored by
About this trial
This is an interventional diagnostic trial for Duchenne Muscular Dystrophy
Eligibility Criteria
Inclusion Criteria:
- Duchenne's muscular dystrophy (group 1) followed in our institution's referral center of neuromuscular diseases, during regular annual echocardiography follow-up.
- Healthy children (group 2), addressed in pediatric cardiology
Sites / Locations
- Pediatric and Congenital Cardiology and Pulmonology Department, Arnaud De Villeneuve University Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Other
Arm Label
dmd children
healthy children
Arm Description
echocardiography
echocardiography
Outcomes
Primary Outcome Measures
global longitudinal LV 2D strain
Secondary Outcome Measures
Full Information
NCT ID
NCT02418338
First Posted
April 13, 2015
Last Updated
June 5, 2019
Sponsor
University Hospital, Montpellier
1. Study Identification
Unique Protocol Identification Number
NCT02418338
Brief Title
2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
Official Title
Evaluation of Myocardial Function by Two Dimensional Speckle Tracking Echocardiography in Children With Duchenne Muscular Dystrophy Versus Healthy Children: a Comparative Transversal Multicenter Study
Study Type
Interventional
2. Study Status
Record Verification Date
June 2019
Overall Recruitment Status
Completed
Study Start Date
January 2014 (undefined)
Primary Completion Date
June 2017 (Actual)
Study Completion Date
June 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Montpellier
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Compare systolic function of left ventricle (LV) and right ventricle (VD) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
Detailed Description
Among the new echocardiographic techniques, two dimensional Speckle Tracking Imaging or "2D Strain" allows a dynamic study of regionalized and global ventricular contraction. With software for the spatial and temporal processing of a standard 2D image, this technique measures the displacement of natural markers present on the myocardial wall.
Used in adult cardiology since 2000, it could be eligible to pediatric population because of many potential applications. In Duchenne muscular dystrophy, myocardial disease leads to death in the third decade. Early diagnosis and preventive therapy remain a challenge. No clinic, biologic or radiologic markers can predict myocardial disease before advanced and irreversible heart failure.
Recent animals and human studies suggest that 2D strain anomalies could predict left ventricular systolic dysfunction in Duchenne muscular dystrophy. If it is confirmed, 2D strain could be used as early marker of myocardial disease in routine patient follow-up and in future therapeutic studies.
Purpose : - To compare systolic function of left ventricle (LV) and right ventricle (RV) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
To correlate 2D Strain variables to conventional LV and RV echo variables.
To evaluate 2D strain feasibility in normal children and Duchenne muscular myopathy population
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Duchenne Muscular Dystrophy
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
99 (Actual)
8. Arms, Groups, and Interventions
Arm Title
dmd children
Arm Type
Experimental
Arm Description
echocardiography
Arm Title
healthy children
Arm Type
Other
Arm Description
echocardiography
Intervention Type
Other
Intervention Name(s)
speckle tracking (2D strain) echocardiography
Intervention Description
2D echocardiography videos of both ventricles to perform 2D strain post-examination evaluation
Primary Outcome Measure Information:
Title
global longitudinal LV 2D strain
Time Frame
day 1
10. Eligibility
Sex
All
Maximum Age & Unit of Time
17 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Duchenne's muscular dystrophy (group 1) followed in our institution's referral center of neuromuscular diseases, during regular annual echocardiography follow-up.
Healthy children (group 2), addressed in pediatric cardiology
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pascal AMEDRO, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Pierre MP Meyer, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Arnaud BERTRAND, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Jean-Michel RAUZIER, MD, PhD
Organizational Affiliation
UH Nîmes
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Charlène BREDY, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
François RIVIER, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Grégoire DE LA VILLEON, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Ulrike WALTHER-LOUVIER, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Sophie GUILLAUMONT, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Camille SOULATGES, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Marie VINCENTI, MD, PhD
Organizational Affiliation
UH Montpellier
Official's Role
Principal Investigator
Facility Information:
Facility Name
Pediatric and Congenital Cardiology and Pulmonology Department, Arnaud De Villeneuve University Hospital
City
Montpellier
ZIP/Postal Code
34295
Country
France
12. IPD Sharing Statement
Citations:
PubMed Identifier
30679141
Citation
Amedro P, Vincenti M, De La Villeon G, Lavastre K, Barrea C, Guillaumont S, Bredy C, Gamon L, Meli AC, Cazorla O, Fauconnier J, Meyer P, Rivier F, Adda J, Mura T, Lacampagne A. Speckle-Tracking Echocardiography in Children With Duchenne Muscular Dystrophy: A Prospective Multicenter Controlled Cross-Sectional Study. J Am Soc Echocardiogr. 2019 Mar;32(3):412-422. doi: 10.1016/j.echo.2018.10.017. Epub 2019 Jan 21.
Results Reference
background
PubMed Identifier
34905152
Citation
Lanot N, Vincenti M, Abassi H, Bredy C, Agullo A, Gamon L, Mura T, Lavastre K, De La Villeon G, Barrea C, Meyer P, Rivier F, Meli AC, Fauconnier J, Cazorla O, Lacampagne A, Amedro P. Assessment of left ventricular dyssynchrony by speckle tracking echocardiography in children with duchenne muscular dystrophy. Int J Cardiovasc Imaging. 2022 Jan;38(1):79-89. doi: 10.1007/s10554-021-02369-y. Epub 2021 Dec 14.
Results Reference
derived
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2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
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