Olive Leaf Extract as Part of a Healthy Lifestyle in the Reduction of Blood Pressure
Pre Hypertension
About this trial
This is an interventional prevention trial for Pre Hypertension
Eligibility Criteria
Inclusion Criteria:
- Men and women
- 25-70y
- BMI >25kg/m2
- Not having suffered a myocardial infarction/stroke in the past 12 months
- Not diabetic (diagnosed or fasting glucose > 7 mmol/l) or suffer from other endocrine disorders
- Not suffering from renal or bowel disease or have a history of cholestatic liver or pancreatitis
- Not on drug treatment for hyperlipidaemia, hypertension, inflammation or hypercoagulation
- No history of alcohol misuse
- Not planning or on a weight reducing regime
- Not taking any fish oil, fatty acid or vitamin and mineral supplements
- Non smokers
Exclusion Criteria:
- Use of antibiotics within the previous 6 months
- History of alcohol or drug abuse
- Intake of any experimental drug within 4 weeks of the start of the study
- Excessive alcohol consumption (more than 21 units/wk male, 15 units/wk female)
- Females who are breast-feeding, may be pregnant, or of child-bearing potential and not using effective contraceptive precautions
- Have had recently (in the last 5 years) major surgery, which might limit participation in, or completion of, the study.
- On drug treatment for high blood fats, high blood pressure and blood clotting.
- Physical or mental diseases that are likely to limit participation or completion of the study
Sites / Locations
- Hugh Sinclair Unit of Human Nutrition
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Placebo Comparator
Active Comparator
Placebo control
Olive leaf extract
Physical activity
Physical activity and olive leaf extract
2 capsules of 350 mg maltodextrin to be consumed daily for 12 weeks
2 capsules of 350 mg olive leaf extract equivalent 132 mg of oleuropein in olive leaf extract to be consumed daily for 12 weeks
2 capsules of 350 mg maltodextrin to be consumed daily combined with gradually increase physical activity levels over 12 weeks
2 capsules of 350 mg olive leaf extract equivalent 132 mg of oleuropein in olive leaf extract to be consumed daily combined with gradually increase physical activity levels over 12 weeks