A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation (REDLIT)
Liver Transplantation, Reperfusion, Delayed Graft Function
About this trial
This is an interventional prevention trial for Liver Transplantation focused on measuring Liver Transplantation, Retrograde Reperfusion, Graft dysfunction, Randomized study
Eligibility Criteria
Donor Inclusion Criteria:
- deceased brain dead
- age 18-59
- length of ICU treatment up to 7 days
- highest AST and ALT up to 200 UI/L
- macroscopic steatosis up to 30%
- highest serum sodium up to 165 mmol/L
- highest bilirubin 25 µmol/L
- application of norepinephrine is allowed
- preservation solution - HTK (Custodiol)
Recipient inclusion Criteria:
- age 18-69
- primary liver transplant
- full-size transplant
Technique of liver transplant:
- with IVC resection;
- without veno-venous bypass;
- sequential portal-arterial reperfusion
- flushing of portal vascular bed with 500 ml of called to 2-4 °C saline at back-table before implantataion
Recipient exclusion Criteria:
- live donor liver transplant
- reduced and split grafts;
- multi organ failure (including fulminant and UNOS status 1);
- fulminant hepatic failure
Sites / Locations
- RSPC for organ and tissue transplantation, Minsk 9th clinicRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Retrograde reperfusion
Antegrade reperfusion
During the transplant procedure the liver is initially reperfused retrogradely via hepatic veins. Venting of 300 ml blood is allowed via donor portal vein. After completion the portal vein anastomosis and retrograde venting of another 100 ml blood the antegrade portal reperfusion is performed.
During the transplant procedure the liver is reperfused conventionally, antegradely via portal vein after completion of caval and portal anastomoses. Venting of 300 ml blood is allowed via tube placed in infrahepatiс caval anastomosis before unclamping the vena cava.