Assessment of Cerebral Vasoreactivity Using Near-infrared Spectroscopy (NIRS) in Infants (VARO) (VARO)
Hypercapnia
About this trial
This is an interventional supportive care trial for Hypercapnia focused on measuring spectroscopy, near-infrared, Infant, Anesthesia, general
Eligibility Criteria
Inclusion Criteria:
- term neonates during their infancy
- for elective surgery requiring general anesthesia and endotracheal intubation
Exclusion Criteria:
- all infants with cardiac anomalies, chronic pulmonary disease (bronchopulmonary dysplasia, cystic fibrosis, asthma), pulmonary hypertension or cranial hypertension will be excluded
- all infants where no access to the forehead is possible as a consequence of the operating field
Sites / Locations
- Geneva Children's Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Other
Normocapnia
Mild Hypercapnia
The Child will be ventilated in order to achieve an end-tidal carbon dioxide (ETCO2) of 5.5 kiloPascal (kPa). Measurements will be performed after steady state condition. Then the ventilation will be reduced to allow ETCO2 to reach 6.5 kPa before repeating the measurements. Finally, the child will be again ventilated to obtain a normocapnia condition.
The Child will be ventilated in order to achieve a ETCO2 of 6.5 kPa. Measurements will be performed after steady state condition. Then the ventilation will be increased to allow ETCO2 to reach 5.5 kPa before repeating the measurements. Finally, the child will be again ventilated to obtain a mild hypercapnic condition