Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
About this trial
This is an interventional supportive care trial for Pulmonary Arteriovenous Malformations focused on measuring workload, oxygen level, oxygen consumption, breathing reserve, ventilatory efficiency
Eligibility Criteria
Inclusion Criteria:
- Ability to provide informed consent
- Healthy volunteers: no concurrent health reason to avoid exercise
- Pulmonary AVMs: pulmonary AVMs confirmed by CT scan
- Hereditary hemorrhagic telangiectasia without pulmonary AVMs: HHT according to current international consensus criteria, with no evidence of PAVMs on dedicated thoracic CT scan.
Exclusion Criteria:
- Inability to provide informed consent.
- Any known cardiovascular abnormality including a history of syncope (faintness, dizziness, lightheadedness or loss of consciousness due to an abnormality of the cardiovascular system).
- Current respiratory tract infection (eg a cold).
- Pregnancy.
- Claustrophobia or needle phobia
Sites / Locations
- Hammersmith Hospital, Du Cane Rd
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Healthy control
Pulmonary AVM
HHT but no pulmonary AVM
A group of up to 30 healthy controls will be recruited to have a cardiopulmonary exercise test and a blood test.
A group of up to 30 pulmonary AVM patients will be recruited to have a cardiopulmonary exercise test, and a blood test.
Most patients with pulmonary AVMs have underlying hereditary hemorrhagic telangiectasia (HHT). If there is a difference between pulmonary AVM and control groups that does not correct following embolization of pulmonary AVMs, a group of up to 30 people with HHT but no evidence of pulmonary AVMs will be selected to have a cardiopulmonary exercise test and a blood test.