Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
About this trial
This is an interventional treatment trial for NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Eligibility Criteria
Inclusion Criteria:
- Patients with recent onset ( within 2 weeks) of non-arteritic ischemic optic neuropathy
Exclusion Criteria:
- the presence of glaucoma, or any other ocular, neurologic, or systemic disease that may influence visual acuity and visual field; abnormal results in laboratory assessments, including an abnormally elevated erythrocyte sedimentation rate and positive serum C-reactive protein;
- a history of previous ocular surgery;
- a history of prior treatment of any type for NAION;
- systemic condition such as diabetes mellitus and poorly controlled hypertension
Sites / Locations
- Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Active Comparator
prescription placebo
prescription Intravenous methylprednisolone
prescription normobaric oxygen with face mask
control Group consisted of 30 patients who received gelatinous capsules filled with sugar as placebo
Group 2 or steroid consisted of 30 patients received methylprednisolone (Solu-Medrol, Pharmacia Pharmaceutical Company, Belgium) 500 mg twice a day for 3 days followed by 2 weeks of oral prednisolone 1mg/kg/day
Thirty patients in group 3 or oxygen received 100% normobaric oxygen with face mask in sitting position, at a flow rate of 5 liters per minute for 1 hour twice a day for two weeks