Thromboelastometry-guided Treatment Protocol Versus Standard Care of Major Haemorrhage in Obstetric Patients (ROTEM-PPH)
Obstetric Labor Complications, Hemorrhage
About this trial
This is an interventional treatment trial for Obstetric Labor Complications focused on measuring Thromboelastometry, Obstetric Hemorrhage, Blood Component Transfusion
Eligibility Criteria
Inclusion Criteria:
- Age over 18
- Severe post-partum haemorrhage ie. active bleeding of more than 1000ml within 24 hours after vaginal delivery or cesarean section
- Informed consent (after randomization)
Exclusion Criteria:
- Known hemophilia or von Willebrand's disease
- Unacceptance of allogeneic blood products(Jehovah's witnesses)
Sites / Locations
- Tampere University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Rotational thromboelastometry (ROTEM)
Standard care
Rotational thromboelastometry results are used to guide the treatment of major obstetric hemorrhage, eg. administration of prothrombin complex concentrate, fresh-frozen plasma, fibrinogen concentrate or platelets. In case of massive hemorrhage, "shock packs" of blood products in 1:1:1 ratio are administered.
Patients are treated according to clinical decision making and conventional coagulation tests, and in case of massive hemorrhage, "shock packs" are administered.