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Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration

Primary Purpose

Macular Degeneration

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Abicipar Pegol
Ranibizumab
Sham Procedure
Sponsored by
Allergan
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Macular Degeneration

Eligibility Criteria

50 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Diagnosis of age-related macular degeneration in at least 1 eye
  • Best corrected visual acuity of 20/40 to 20/320 in the study eye
  • Best corrected visual acuity of 20/200 or better in the non-study eye

Exclusion Criteria:

  • History of vitrectomy, macular surgery, or glaucoma surgery in the study eye
  • Cataract or refractive surgery in the study eye within the last 3 months

Sites / Locations

  • Eye Foundation Hospital
  • Retinal Consultants of Arizona
  • Barnet Dulaney Perkins Eye Center - Phoenix
  • Retina Centers, PC
  • Northwest Arkansas Retina Associates
  • Win Retina
  • Retina Institute of California
  • Retinal Diagnostic Center
  • Specialty Eye Care Medical Center, Inc.
  • University of California at Irvine Gavin Herbert Eye Institute
  • Retina Associates of Orange County
  • South Coast Retina Center
  • East Bay Retina Consultants, Inc.
  • San Diego Retina Associates
  • Southern California Desert Retina Consultants
  • California Eye Specialist Medical Group
  • Retina Consultants, San Diego
  • Retina Consultants of Southern California
  • Kaiser Permanente Riverside Medical Center
  • UC Davis Medical Center, Department of Ophthalmology
  • Retinal Consultants Medical Group, Inc.
  • West Coast Retina Medical Group
  • Pacific Eye Associates
  • The Eye Associates
  • National Ophthalmic Research Institute
  • Retina Macula Specialists of Miami
  • MedEye Associates
  • Fort Lauderdale Eye Institute
  • Sarasota Retina Institute
  • East Florida Eye Institute
  • Retina Associate of Florida, P.A.
  • Retina Vitreous Associates of Florida
  • Center for Retina and Macular Disease
  • Southeast Retina Center
  • Rush University Medical Center
  • DuPage Medical Group
  • Kovach Eye Institute
  • University Retina and Macula Associates
  • Wheaton Eye Clinic, Clinical Research Center, LLC
  • Sabates Eye Centers
  • Paducah Retinal Center
  • The Retina Care Center
  • Cumberland Valley Retina Consultants, P.C.
  • Vitreo-Retinal Associates, Pc
  • Retina Specialists of Michigan
  • University of Mississippi Medical Center
  • Retina Center of New Jersey, LLC
  • Delaware Valley Retina Associates
  • Long Island Vitreoretinal Consultants
  • Maculacare - New York
  • Retina Vitreous Surgeons of Central NY, PC
  • Western Carolina Retinal Associates, PA
  • Charlotte Eye Ear Nose & Throat Associates, PA
  • Retina Associates of Cleveland, Inc
  • Cincinnati Eye Institute
  • Ohio State University
  • Midwest Retina, Inc.
  • Retina & Vitreous Center SO, PC
  • Oregon Health Sciences University
  • Pennsylvania Retina Specialists, P.C.
  • Black Hills Regional Eye Institute
  • Austin Retina Associates
  • Retina and Vitreous of Texas
  • The University of Texas Medical Branch
  • Premiere Retina Specialists
  • Retina Associates of South Texas, PA
  • Strategic Clinical Research Group, LLC
  • University of Utah, John Moran Eye Center
  • Virginia Eye Consultants
  • Wagner Macula and Retina Center
  • Vitreoretinal Associates of Washington
  • Spokane Eye Clinical Research
  • West Virginia University Eye Institute
  • Save Sight Institute, University of Sydney Eye Hospital
  • Sydney Retina Clinic and Day Surgery
  • Sydney West Retina
  • Centre for Eye Research Australia
  • Specialist Eye Group
  • Lions Eye Institute
  • Centro Brasileiro de Cirurgia de Olhos - CBCO
  • Instistuto da Visao - Hospital de Olhos Ltda
  • Hospital Oftalmologico de Sorocaba
  • Clinica de Olhos Dr. Suel Abujamra
  • Instituto Da Visao UNIFESP EPM (Universidade Federal de Sao Paulo - Escola Paulista de Medicina)
  • Calgary Retina Consultants
  • St Joseph's Health Care London - Ivey Eye Institute
  • Canadian Centre for Advanced Eye Therapeutics Inc
  • University of Ottawa Eye Institute
  • Toronto Retina Institute
  • Rigshospitalet-Glostrup
  • Odense University Hospital
  • Magyar Honvedseg Egeszegugyi Kozpont
  • Semmelweis University
  • Bajcsy-Zsilinszky Hospital
  • Szent Imre Teaching Hospital
  • Budapest Retina Associates Kft.
  • University of Debrecen, Medical Center
  • Ganglion Medical Centre
  • University of Szeged
  • Markusovszki Teaching Hospital
  • Ospedale Clinicizzato
  • Clinica Oculistica, Ospedale Santa Maria della Misericordia
  • Eye Clinic - Fondazione IRCCS
  • Clinica Oculistica- Dipartimento di Scienze Cliniche Universita di Milano
  • Ospedale Molinette
  • Azienda Ospedaliero-Universitaria Careggi - SOD Oculistica, Dipartimento di Chirurgia e Medicina Traslazionale
  • Azienda Universitaria Ospedaliera Pisana, Ospedale "Nuovo S.Chiara" Cisanello
  • IRCCS - Istuto di Recovero e Cura a Carattere Scientifico
  • A.O.U. Policlinico Sant Orsola Malpighi Pad1, 4Piano, Studio Medici via Pelagio Palagi 9
  • Clinica Oculistica DINOGMI Universita di Genova
  • IRCCS Ospedale San Raffaele
  • Policlinico Agostino Gemelli
  • Fondazione G.B. Bietti-IRCCS
  • Aichi Medical University Hospital
  • Japan Community Health Care Organization Chukyo Hospital
  • Nagoya University Hospital
  • Kameda Clinic
  • Toho University Sakura Medical Center
  • Juntendo University Urayasu Hospital
  • Ogaki Tokushukai Hospital
  • Kimura Eye And Internal Medicine Hospital
  • Sapporo City General Hospital
  • Hyogo Prefectural Amagasaki Hospital General Medical Center
  • Tokyo Medical University Ibaraki Medical Center
  • Mito Kyodo General Hospital
  • Otakeganka Tsukimino Clinic
  • Kikuna Yuda Eye Clinic
  • Mie University Hospital
  • Iida Municipal Hospital
  • Shiga University of Medical Science Hospital
  • Seirei Hamamatsu General Hospital
  • Nihon University Hospital
  • Chofu Eye Clinic
  • Tokyo Medical University Hachioji Medical Center
  • Takeuchi Eye Clinic
  • Kyushu University Hospital
  • Fukushima Medical University Hospital
  • Kokura Kinen Hospital
  • Ideta Eye Hospital
  • The Japanese Red Cross Nagasaki Genbaku Hospital
  • Nara Medical University Hospital
  • Medical Corporation Jinshikai Nishi Eye Hospital
  • Musashi Dream Clinic
  • Tane Memorial Eye Hospital
  • Tokyo Women's Medical University Hospital
  • Elisabeth Hospital
  • Academic Medical Center
  • Oogziekenhuis Rotterdam
  • Leiden University Medical Center
  • Macula D&T Eye Center
  • Optimum Profesorskie Centrum Okulistyki
  • Klinika Okulistyczna Jasne Blonia
  • Centrum Diagnostyki i Mikrochirurgii
  • Retina Eye Hospital
  • Uniwersytecki Szpital Kliniczny
  • Scientific Research Institute of Ocular Diseases of RAMS
  • S. Fyodorov Eye Microsurgery Federal State Institution
  • Pasteur Medical Centre
  • Dr Actons Privat Practice
  • Pretoria Eye Institute, Private Practice
  • Department of Ophthalmology Kaohsiung Veterans General Hospital
  • Kaohsiung Chang Gung Memorial Hospital
  • Department of Ophthalmology National Taiwan University Hospital
  • Shin Kong Wu Ho-Su Memorial Hospital
  • Chang Gung Medical Foundation, Linkou Branch
  • Ankara Uni Med Fac
  • Dokuz Eylul Uni Med Fac
  • Frimley Park Hospital
  • Royal Derby Hospital
  • ESNEFT Essex County Hospital
  • University Hospital Southampton
  • Oxford Eye Hospital, John Radcliffe Hospital
  • Royal Liverpool University Hospital
  • Royal Surrey Hospital
  • Heart of England NHS Foundation Trust, Good Hope Hospital
  • University Hospital of Wales
  • Bradford Royal Infirmary (BRI)
  • Sheffield Teaching Hospitals
  • Barnet Hospital
  • Bristol Eye Hospital
  • University Hospital Aintree
  • Moorfields Eye Hospital
  • Barnet Royal Free Hospital
  • King's College Hospital
  • Royal Victoria Infirmary
  • Hospital of St. Cross
  • City Hospitals Sunderland NHS

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Abicipar Pegol 2 mg (2Q8)

Abicipar Pegol 2 mg (2Q12)

Ranibizumab (rQ4)

Arm Description

Abicipar pegol 2 mg was administered to the study eye by intravitreal injection on Day 1, Week 4, and Week 8, followed by injections every 8 weeks through Week 96. Scheduled visits occurred every 4 weeks. To maintain masking, sham was administered to the study eye at scheduled visits where abicipar was not administered.

Abicipar pegol 2 mg was administered to the study eye by intravitreal injection on Day 1, Week 4, and Week 12, followed by injections every 12 weeks through Week 96. Scheduled visits occurred every 4 weeks. To maintain masking, sham was administered to the study eye at scheduled visits where abicipar was not administered.

Ranibizumab (Lucentis®) was administered to the study eye by intravitreal injection every 4 weeks from Day 1 through Week 96.

Outcomes

Primary Outcome Measures

Percentage of Participants With Stable Vision at Week 52
Stable vision was defined as vision loss of fewer than 15 letters in Best-corrected Visual Acuity (BCVA) from baseline. BCVA is measured using an eye chart and is reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The percentage of participants with a BCVA loss of fewer than 15 letters are reported. Study eye was defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.

Secondary Outcome Measures

Mean Change From Baseline in Best-corrected Visual Acuity (BCVA) in the Study Eye at Week 52
BCVA was measured using an eye chart and is reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. Mixed-effect model for repeated measures (MMRM) analysis was used. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.
Mean Change From Baseline in Central Retinal Thickness (CRT) in the Study Eye at Week 52
CRT was assessed using spectral domain optical coherence tomography (SD-OCT), a non-invasive diagnostic system that provides high-resolution imaging sections of the retina. SD-OCT is performed in the study eye after pupil dilation. A negative change from Baseline indicates improvement and a positive change from baseline indicates worsening. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye. MMRM analysis was used.
Percentage of Participants With BCVA Gain of More Than 15 Letters From Baseline in the Study Eye at Week 52
BCVA is measured using an eye chart and is reported as the number of letters read correctly using the Early Treatment of Diabetic Retinopathy Study (ETDRS) Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The percentage of participants with a BCVA gain of more than 15 letters are noted. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.
Mean Change From Baseline in the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Composite Score at Week 52
NEI-VFQ-25 consists of 25 vision-targeted questions that represent 11 vision-related quality of life subscales and one general health item. Responses of individual participants were recorded as scores that ranged between 0 (worst) to 100 (best vision related function) with higher scale indicating better vision. Overall composite score is then calculated by averaging over all 11 vision-targeted subscale scores, excluding general health score. Overall composite score was calculated based on mean of non-missing subscales. Study eye: eye that meets entry criteria. If both eyes met all of entry criteria, eye with worse BCVA at baseline (day 1) was selected. If BCVA values for both eyes were identical then participant had to select non-dominant eye, or else right eye was selected as study eye. A positive change from baseline indicates improvement. MMRM analysis was used.

Full Information

First Posted
June 2, 2015
Last Updated
July 17, 2020
Sponsor
Allergan
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1. Study Identification

Unique Protocol Identification Number
NCT02462486
Brief Title
Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration
Official Title
Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients With Neovascular Age-related Macular Degeneration (SEQUOIA Study)
Study Type
Interventional

2. Study Status

Record Verification Date
July 2020
Overall Recruitment Status
Completed
Study Start Date
June 25, 2015 (Actual)
Primary Completion Date
April 12, 2018 (Actual)
Study Completion Date
June 6, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Allergan

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is a safety and efficacy study of abicipar pegol in participants with neovascular age-related macular degeneration.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Macular Degeneration

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
949 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Abicipar Pegol 2 mg (2Q8)
Arm Type
Experimental
Arm Description
Abicipar pegol 2 mg was administered to the study eye by intravitreal injection on Day 1, Week 4, and Week 8, followed by injections every 8 weeks through Week 96. Scheduled visits occurred every 4 weeks. To maintain masking, sham was administered to the study eye at scheduled visits where abicipar was not administered.
Arm Title
Abicipar Pegol 2 mg (2Q12)
Arm Type
Experimental
Arm Description
Abicipar pegol 2 mg was administered to the study eye by intravitreal injection on Day 1, Week 4, and Week 12, followed by injections every 12 weeks through Week 96. Scheduled visits occurred every 4 weeks. To maintain masking, sham was administered to the study eye at scheduled visits where abicipar was not administered.
Arm Title
Ranibizumab (rQ4)
Arm Type
Active Comparator
Arm Description
Ranibizumab (Lucentis®) was administered to the study eye by intravitreal injection every 4 weeks from Day 1 through Week 96.
Intervention Type
Drug
Intervention Name(s)
Abicipar Pegol
Other Intervention Name(s)
AGN-150998
Intervention Description
Abicipar pegol intravitreal injection.
Intervention Type
Drug
Intervention Name(s)
Ranibizumab
Other Intervention Name(s)
Lucentis®
Intervention Description
Ranibizumab intravitreal injection.
Intervention Type
Other
Intervention Name(s)
Sham Procedure
Intervention Description
Sham injection.
Primary Outcome Measure Information:
Title
Percentage of Participants With Stable Vision at Week 52
Description
Stable vision was defined as vision loss of fewer than 15 letters in Best-corrected Visual Acuity (BCVA) from baseline. BCVA is measured using an eye chart and is reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The percentage of participants with a BCVA loss of fewer than 15 letters are reported. Study eye was defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.
Time Frame
Baseline to Week 52
Secondary Outcome Measure Information:
Title
Mean Change From Baseline in Best-corrected Visual Acuity (BCVA) in the Study Eye at Week 52
Description
BCVA was measured using an eye chart and is reported as the number of letters read correctly using the ETDRS Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. Mixed-effect model for repeated measures (MMRM) analysis was used. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.
Time Frame
Baseline to Week 52
Title
Mean Change From Baseline in Central Retinal Thickness (CRT) in the Study Eye at Week 52
Description
CRT was assessed using spectral domain optical coherence tomography (SD-OCT), a non-invasive diagnostic system that provides high-resolution imaging sections of the retina. SD-OCT is performed in the study eye after pupil dilation. A negative change from Baseline indicates improvement and a positive change from baseline indicates worsening. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye. MMRM analysis was used.
Time Frame
Baseline to Week 52
Title
Percentage of Participants With BCVA Gain of More Than 15 Letters From Baseline in the Study Eye at Week 52
Description
BCVA is measured using an eye chart and is reported as the number of letters read correctly using the Early Treatment of Diabetic Retinopathy Study (ETDRS) Scale (ranging from 0 to 100 letters) in the study eye. The lower the number of letters read correctly on the eye chart, the worse the vision (or visual acuity). An increase in the number of letters read correctly means that vision has improved. The percentage of participants with a BCVA gain of more than 15 letters are noted. Study eye is defined as the eye that meets the entry criteria. If both the eyes met all of the entry criteria, the eye with worse BCVA at baseline (Day 1) was selected. If BCVA values for both eyes were identical then participant had to select the non-dominant eye, or else right eye was selected as study eye.
Time Frame
Baseline to Week 52
Title
Mean Change From Baseline in the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Composite Score at Week 52
Description
NEI-VFQ-25 consists of 25 vision-targeted questions that represent 11 vision-related quality of life subscales and one general health item. Responses of individual participants were recorded as scores that ranged between 0 (worst) to 100 (best vision related function) with higher scale indicating better vision. Overall composite score is then calculated by averaging over all 11 vision-targeted subscale scores, excluding general health score. Overall composite score was calculated based on mean of non-missing subscales. Study eye: eye that meets entry criteria. If both eyes met all of entry criteria, eye with worse BCVA at baseline (day 1) was selected. If BCVA values for both eyes were identical then participant had to select non-dominant eye, or else right eye was selected as study eye. A positive change from baseline indicates improvement. MMRM analysis was used.
Time Frame
Baseline to Week 52

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Diagnosis of age-related macular degeneration in at least 1 eye Best corrected visual acuity of 20/40 to 20/320 in the study eye Best corrected visual acuity of 20/200 or better in the non-study eye Exclusion Criteria: History of vitrectomy, macular surgery, or glaucoma surgery in the study eye Cataract or refractive surgery in the study eye within the last 3 months
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Joanne Li
Organizational Affiliation
Allergan
Official's Role
Study Director
Facility Information:
Facility Name
Eye Foundation Hospital
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35233
Country
United States
Facility Name
Retinal Consultants of Arizona
City
Gilbert
State/Province
Arizona
ZIP/Postal Code
85296
Country
United States
Facility Name
Barnet Dulaney Perkins Eye Center - Phoenix
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85016-4701
Country
United States
Facility Name
Retina Centers, PC
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85704
Country
United States
Facility Name
Northwest Arkansas Retina Associates
City
Springdale
State/Province
Arkansas
ZIP/Postal Code
72762
Country
United States
Facility Name
Win Retina
City
Arcadia
State/Province
California
ZIP/Postal Code
91006
Country
United States
Facility Name
Retina Institute of California
City
Arcadia
State/Province
California
ZIP/Postal Code
91007
Country
United States
Facility Name
Retinal Diagnostic Center
City
Campbell
State/Province
California
ZIP/Postal Code
95008
Country
United States
Facility Name
Specialty Eye Care Medical Center, Inc.
City
Glendale
State/Province
California
ZIP/Postal Code
91203
Country
United States
Facility Name
University of California at Irvine Gavin Herbert Eye Institute
City
Irvine
State/Province
California
ZIP/Postal Code
92697-4375
Country
United States
Facility Name
Retina Associates of Orange County
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
South Coast Retina Center
City
Long Beach
State/Province
California
ZIP/Postal Code
90807
Country
United States
Facility Name
East Bay Retina Consultants, Inc.
City
Oakland
State/Province
California
ZIP/Postal Code
94609
Country
United States
Facility Name
San Diego Retina Associates
City
Oceanside
State/Province
California
ZIP/Postal Code
92056
Country
United States
Facility Name
Southern California Desert Retina Consultants
City
Palm Desert
State/Province
California
ZIP/Postal Code
92211
Country
United States
Facility Name
California Eye Specialist Medical Group
City
Pasadena
State/Province
California
ZIP/Postal Code
91107
Country
United States
Facility Name
Retina Consultants, San Diego
City
Poway
State/Province
California
ZIP/Postal Code
92064
Country
United States
Facility Name
Retina Consultants of Southern California
City
Redlands
State/Province
California
ZIP/Postal Code
92374
Country
United States
Facility Name
Kaiser Permanente Riverside Medical Center
City
Riverside
State/Province
California
ZIP/Postal Code
92505
Country
United States
Facility Name
UC Davis Medical Center, Department of Ophthalmology
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
Retinal Consultants Medical Group, Inc.
City
Sacramento
State/Province
California
ZIP/Postal Code
95841
Country
United States
Facility Name
West Coast Retina Medical Group
City
San Francisco
State/Province
California
ZIP/Postal Code
94109
Country
United States
Facility Name
Pacific Eye Associates
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
The Eye Associates
City
Bradenton
State/Province
Florida
ZIP/Postal Code
34209
Country
United States
Facility Name
National Ophthalmic Research Institute
City
Fort Myers
State/Province
Florida
ZIP/Postal Code
33912
Country
United States
Facility Name
Retina Macula Specialists of Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33126
Country
United States
Facility Name
MedEye Associates
City
Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
Fort Lauderdale Eye Institute
City
Plantation
State/Province
Florida
ZIP/Postal Code
33324
Country
United States
Facility Name
Sarasota Retina Institute
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
East Florida Eye Institute
City
Stuart
State/Province
Florida
ZIP/Postal Code
34994
Country
United States
Facility Name
Retina Associate of Florida, P.A.
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
Facility Name
Retina Vitreous Associates of Florida
City
Tampa
State/Province
Florida
ZIP/Postal Code
33617
Country
United States
Facility Name
Center for Retina and Macular Disease
City
Winter Haven
State/Province
Florida
ZIP/Postal Code
33880
Country
United States
Facility Name
Southeast Retina Center
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30909
Country
United States
Facility Name
Rush University Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
DuPage Medical Group
City
Downers Grove
State/Province
Illinois
ZIP/Postal Code
60515
Country
United States
Facility Name
Kovach Eye Institute
City
Elmhurst
State/Province
Illinois
ZIP/Postal Code
60126
Country
United States
Facility Name
University Retina and Macula Associates
City
Oak Forest
State/Province
Illinois
ZIP/Postal Code
60452
Country
United States
Facility Name
Wheaton Eye Clinic, Clinical Research Center, LLC
City
Wheaton
State/Province
Illinois
ZIP/Postal Code
60187
Country
United States
Facility Name
Sabates Eye Centers
City
Leawood
State/Province
Kansas
ZIP/Postal Code
66211
Country
United States
Facility Name
Paducah Retinal Center
City
Paducah
State/Province
Kentucky
ZIP/Postal Code
42001
Country
United States
Facility Name
The Retina Care Center
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21209
Country
United States
Facility Name
Cumberland Valley Retina Consultants, P.C.
City
Hagerstown
State/Province
Maryland
ZIP/Postal Code
21740
Country
United States
Facility Name
Vitreo-Retinal Associates, Pc
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01605
Country
United States
Facility Name
Retina Specialists of Michigan
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49546
Country
United States
Facility Name
University of Mississippi Medical Center
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Retina Center of New Jersey, LLC
City
Bloomfield
State/Province
New Jersey
ZIP/Postal Code
07003
Country
United States
Facility Name
Delaware Valley Retina Associates
City
Lawrenceville
State/Province
New Jersey
ZIP/Postal Code
08648
Country
United States
Facility Name
Long Island Vitreoretinal Consultants
City
Hauppauge
State/Province
New York
ZIP/Postal Code
11788
Country
United States
Facility Name
Maculacare - New York
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Retina Vitreous Surgeons of Central NY, PC
City
Syracuse
State/Province
New York
ZIP/Postal Code
13224
Country
United States
Facility Name
Western Carolina Retinal Associates, PA
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28803
Country
United States
Facility Name
Charlotte Eye Ear Nose & Throat Associates, PA
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28210
Country
United States
Facility Name
Retina Associates of Cleveland, Inc
City
Beachwood
State/Province
Ohio
ZIP/Postal Code
44122
Country
United States
Facility Name
Cincinnati Eye Institute
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242-5664
Country
United States
Facility Name
Ohio State University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43212
Country
United States
Facility Name
Midwest Retina, Inc.
City
Dublin
State/Province
Ohio
ZIP/Postal Code
43016
Country
United States
Facility Name
Retina & Vitreous Center SO, PC
City
Ashland
State/Province
Oregon
ZIP/Postal Code
97520
Country
United States
Facility Name
Oregon Health Sciences University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Pennsylvania Retina Specialists, P.C.
City
Camp Hill
State/Province
Pennsylvania
ZIP/Postal Code
17011
Country
United States
Facility Name
Black Hills Regional Eye Institute
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57701
Country
United States
Facility Name
Austin Retina Associates
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
Facility Name
Retina and Vitreous of Texas
City
Beaumont
State/Province
Texas
ZIP/Postal Code
77707
Country
United States
Facility Name
The University of Texas Medical Branch
City
Galveston
State/Province
Texas
ZIP/Postal Code
77550
Country
United States
Facility Name
Premiere Retina Specialists
City
Midland
State/Province
Texas
ZIP/Postal Code
79706
Country
United States
Facility Name
Retina Associates of South Texas, PA
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78240
Country
United States
Facility Name
Strategic Clinical Research Group, LLC
City
Willow Park
State/Province
Texas
ZIP/Postal Code
76087
Country
United States
Facility Name
University of Utah, John Moran Eye Center
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84132
Country
United States
Facility Name
Virginia Eye Consultants
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23502
Country
United States
Facility Name
Wagner Macula and Retina Center
City
Virginia Beach
State/Province
Virginia
ZIP/Postal Code
23454
Country
United States
Facility Name
Vitreoretinal Associates of Washington
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004
Country
United States
Facility Name
Spokane Eye Clinical Research
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
West Virginia University Eye Institute
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26506
Country
United States
Facility Name
Save Sight Institute, University of Sydney Eye Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2000
Country
Australia
Facility Name
Sydney Retina Clinic and Day Surgery
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2000
Country
Australia
Facility Name
Sydney West Retina
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Facility Name
Centre for Eye Research Australia
City
East Melbourne
State/Province
Victoria
ZIP/Postal Code
3002
Country
Australia
Facility Name
Specialist Eye Group
City
Glen Waverley
State/Province
Victoria
ZIP/Postal Code
3150
Country
Australia
Facility Name
Lions Eye Institute
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Centro Brasileiro de Cirurgia de Olhos - CBCO
City
Goiania
State/Province
Goias
ZIP/Postal Code
74210-010
Country
Brazil
Facility Name
Instistuto da Visao - Hospital de Olhos Ltda
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30330-000
Country
Brazil
Facility Name
Hospital Oftalmologico de Sorocaba
City
Sorocaba
State/Province
Sao Paulo
ZIP/Postal Code
18031-060
Country
Brazil
Facility Name
Clinica de Olhos Dr. Suel Abujamra
City
Sao Paulo
ZIP/Postal Code
01525-001
Country
Brazil
Facility Name
Instituto Da Visao UNIFESP EPM (Universidade Federal de Sao Paulo - Escola Paulista de Medicina)
City
Sao Paulo
ZIP/Postal Code
04023-062
Country
Brazil
Facility Name
Calgary Retina Consultants
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2H 0C8
Country
Canada
Facility Name
St Joseph's Health Care London - Ivey Eye Institute
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4V2
Country
Canada
Facility Name
Canadian Centre for Advanced Eye Therapeutics Inc
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L4W 1W9
Country
Canada
Facility Name
University of Ottawa Eye Institute
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
Toronto Retina Institute
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M3C0G9
Country
Canada
Facility Name
Rigshospitalet-Glostrup
City
Glostrup
State/Province
Hovedstaden
ZIP/Postal Code
2600
Country
Denmark
Facility Name
Odense University Hospital
City
Odense
State/Province
Syddanmark
ZIP/Postal Code
C 5000
Country
Denmark
Facility Name
Magyar Honvedseg Egeszegugyi Kozpont
City
Budapest
ZIP/Postal Code
1068
Country
Hungary
Facility Name
Semmelweis University
City
Budapest
ZIP/Postal Code
1085
Country
Hungary
Facility Name
Bajcsy-Zsilinszky Hospital
City
Budapest
ZIP/Postal Code
1106
Country
Hungary
Facility Name
Szent Imre Teaching Hospital
City
Budapest
ZIP/Postal Code
1115
Country
Hungary
Facility Name
Budapest Retina Associates Kft.
City
Budapest
ZIP/Postal Code
1133
Country
Hungary
Facility Name
University of Debrecen, Medical Center
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Ganglion Medical Centre
City
Pecs
ZIP/Postal Code
7621
Country
Hungary
Facility Name
University of Szeged
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Markusovszki Teaching Hospital
City
Szombathely
ZIP/Postal Code
9700
Country
Hungary
Facility Name
Ospedale Clinicizzato
City
Chieti
State/Province
Abruzzi
ZIP/Postal Code
66100
Country
Italy
Facility Name
Clinica Oculistica, Ospedale Santa Maria della Misericordia
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33100
Country
Italy
Facility Name
Eye Clinic - Fondazione IRCCS
City
Milan
State/Province
Lombardy
ZIP/Postal Code
20122
Country
Italy
Facility Name
Clinica Oculistica- Dipartimento di Scienze Cliniche Universita di Milano
City
Milan
State/Province
Lombardy
ZIP/Postal Code
20157
Country
Italy
Facility Name
Ospedale Molinette
City
Torino
State/Province
Piedmont
ZIP/Postal Code
10126
Country
Italy
Facility Name
Azienda Ospedaliero-Universitaria Careggi - SOD Oculistica, Dipartimento di Chirurgia e Medicina Traslazionale
City
Firenze
State/Province
Tuscany
ZIP/Postal Code
50134
Country
Italy
Facility Name
Azienda Universitaria Ospedaliera Pisana, Ospedale "Nuovo S.Chiara" Cisanello
City
Pisa
State/Province
Tuscany
ZIP/Postal Code
56124
Country
Italy
Facility Name
IRCCS - Istuto di Recovero e Cura a Carattere Scientifico
City
Verona
State/Province
Vento
ZIP/Postal Code
37024
Country
Italy
Facility Name
A.O.U. Policlinico Sant Orsola Malpighi Pad1, 4Piano, Studio Medici via Pelagio Palagi 9
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Clinica Oculistica DINOGMI Universita di Genova
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
IRCCS Ospedale San Raffaele
City
Milano
ZIP/Postal Code
20132
Country
Italy
Facility Name
Policlinico Agostino Gemelli
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Fondazione G.B. Bietti-IRCCS
City
Roma
ZIP/Postal Code
00198
Country
Italy
Facility Name
Aichi Medical University Hospital
City
Nagakute
State/Province
Aichi
ZIP/Postal Code
480-1195
Country
Japan
Facility Name
Japan Community Health Care Organization Chukyo Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
457-8510
Country
Japan
Facility Name
Nagoya University Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
466-8560
Country
Japan
Facility Name
Kameda Clinic
City
Kamogawa
State/Province
Chiba
ZIP/Postal Code
296-0041
Country
Japan
Facility Name
Toho University Sakura Medical Center
City
Sakura
State/Province
Chiba
ZIP/Postal Code
285-8741
Country
Japan
Facility Name
Juntendo University Urayasu Hospital
City
Urayasu
State/Province
Chiba
ZIP/Postal Code
279-0021
Country
Japan
Facility Name
Ogaki Tokushukai Hospital
City
Ogaki
State/Province
Gifu
ZIP/Postal Code
503-0015
Country
Japan
Facility Name
Kimura Eye And Internal Medicine Hospital
City
Kure
State/Province
Hiroshima
ZIP/Postal Code
737-0029
Country
Japan
Facility Name
Sapporo City General Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8604
Country
Japan
Facility Name
Hyogo Prefectural Amagasaki Hospital General Medical Center
City
Amagasaki
State/Province
Hyogo
ZIP/Postal Code
660-8550
Country
Japan
Facility Name
Tokyo Medical University Ibaraki Medical Center
City
Inashiki
State/Province
Ibaraki
ZIP/Postal Code
300-0395
Country
Japan
Facility Name
Mito Kyodo General Hospital
City
Mito
State/Province
Ibaraki
ZIP/Postal Code
310-0015
Country
Japan
Facility Name
Otakeganka Tsukimino Clinic
City
Yamato
State/Province
Kanagawa
ZIP/Postal Code
242-0001
Country
Japan
Facility Name
Kikuna Yuda Eye Clinic
City
Kanagawa
State/Province
Kanto
ZIP/Postal Code
222-0011
Country
Japan
Facility Name
Mie University Hospital
City
Tsu
State/Province
Mie
ZIP/Postal Code
514-8507
Country
Japan
Facility Name
Iida Municipal Hospital
City
Iida
State/Province
Nagano
ZIP/Postal Code
395-8502
Country
Japan
Facility Name
Shiga University of Medical Science Hospital
City
Otsu
State/Province
Shiga
ZIP/Postal Code
520-2192
Country
Japan
Facility Name
Seirei Hamamatsu General Hospital
City
Hamamatsu
State/Province
Shizuoka
ZIP/Postal Code
430-8558
Country
Japan
Facility Name
Nihon University Hospital
City
Chiyoda
State/Province
Tokyo
ZIP/Postal Code
101-8309
Country
Japan
Facility Name
Chofu Eye Clinic
City
Chofu
State/Province
Tokyo
ZIP/Postal Code
182-0024
Country
Japan
Facility Name
Tokyo Medical University Hachioji Medical Center
City
Hachioji
State/Province
Tokyo
ZIP/Postal Code
193-0998
Country
Japan
Facility Name
Takeuchi Eye Clinic
City
Taito
State/Province
Tokyo
ZIP/Postal Code
111-0051
Country
Japan
Facility Name
Kyushu University Hospital
City
Fukuoka
ZIP/Postal Code
812-8582
Country
Japan
Facility Name
Fukushima Medical University Hospital
City
Fukushima
ZIP/Postal Code
960-1295
Country
Japan
Facility Name
Kokura Kinen Hospital
City
Kitakyushu
ZIP/Postal Code
802-8555
Country
Japan
Facility Name
Ideta Eye Hospital
City
Kumamoto
ZIP/Postal Code
860-0027
Country
Japan
Facility Name
The Japanese Red Cross Nagasaki Genbaku Hospital
City
Nagasaki
ZIP/Postal Code
852-0851
Country
Japan
Facility Name
Nara Medical University Hospital
City
Nara
ZIP/Postal Code
634-8522
Country
Japan
Facility Name
Medical Corporation Jinshikai Nishi Eye Hospital
City
Osaka
ZIP/Postal Code
537-0025
Country
Japan
Facility Name
Musashi Dream Clinic
City
Osaka
ZIP/Postal Code
543-0027
Country
Japan
Facility Name
Tane Memorial Eye Hospital
City
Osaka
ZIP/Postal Code
550-0024
Country
Japan
Facility Name
Tokyo Women's Medical University Hospital
City
Tokyo
ZIP/Postal Code
162-8666
Country
Japan
Facility Name
Elisabeth Hospital
City
Tilburg
State/Province
North Brabant
ZIP/Postal Code
5022 GC
Country
Netherlands
Facility Name
Academic Medical Center
City
Amsterdam
State/Province
North Holland
ZIP/Postal Code
1105 AZ
Country
Netherlands
Facility Name
Oogziekenhuis Rotterdam
City
Rotterdam
State/Province
North Holland
ZIP/Postal Code
3011 BH
Country
Netherlands
Facility Name
Leiden University Medical Center
City
Leiden
State/Province
South Holland
ZIP/Postal Code
2333 ZA
Country
Netherlands
Facility Name
Macula D&T Eye Center
City
San Isidro
State/Province
Lima
ZIP/Postal Code
27
Country
Peru
Facility Name
Optimum Profesorskie Centrum Okulistyki
City
Gdansk
ZIP/Postal Code
80-809
Country
Poland
Facility Name
Klinika Okulistyczna Jasne Blonia
City
Lodz
ZIP/Postal Code
91-134
Country
Poland
Facility Name
Centrum Diagnostyki i Mikrochirurgii
City
Olsztyn
ZIP/Postal Code
10-424
Country
Poland
Facility Name
Retina Eye Hospital
City
Warsaw
ZIP/Postal Code
01-364
Country
Poland
Facility Name
Uniwersytecki Szpital Kliniczny
City
Wrocław
ZIP/Postal Code
50-556
Country
Poland
Facility Name
Scientific Research Institute of Ocular Diseases of RAMS
City
Moscow
ZIP/Postal Code
119021
Country
Russian Federation
Facility Name
S. Fyodorov Eye Microsurgery Federal State Institution
City
Moscow
ZIP/Postal Code
127486
Country
Russian Federation
Facility Name
Pasteur Medical Centre
City
Bloemfontein
ZIP/Postal Code
9301
Country
South Africa
Facility Name
Dr Actons Privat Practice
City
Cape Town
ZIP/Postal Code
7530
Country
South Africa
Facility Name
Pretoria Eye Institute, Private Practice
City
Pretoria
ZIP/Postal Code
0007
Country
South Africa
Facility Name
Department of Ophthalmology Kaohsiung Veterans General Hospital
City
Kaohsiung
ZIP/Postal Code
813
Country
Taiwan
Facility Name
Kaohsiung Chang Gung Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Department of Ophthalmology National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Shin Kong Wu Ho-Su Memorial Hospital
City
Taipei
ZIP/Postal Code
111
Country
Taiwan
Facility Name
Chang Gung Medical Foundation, Linkou Branch
City
Taoyuan
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Ankara Uni Med Fac
City
Ankara
ZIP/Postal Code
06590
Country
Turkey
Facility Name
Dokuz Eylul Uni Med Fac
City
Izmir
ZIP/Postal Code
35340
Country
Turkey
Facility Name
Frimley Park Hospital
City
Frimley
State/Province
Camberley
ZIP/Postal Code
GU17 7UJ
Country
United Kingdom
Facility Name
Royal Derby Hospital
City
Derby
State/Province
Derbyshire
ZIP/Postal Code
DE22 3NE
Country
United Kingdom
Facility Name
ESNEFT Essex County Hospital
City
Colchester
State/Province
Essex
ZIP/Postal Code
CO4 5JR
Country
United Kingdom
Facility Name
University Hospital Southampton
City
Southampton
State/Province
Hampshire
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Facility Name
Oxford Eye Hospital, John Radcliffe Hospital
City
Oxford
State/Province
Headington
ZIP/Postal Code
OX3 9DU
Country
United Kingdom
Facility Name
Royal Liverpool University Hospital
City
Liverpool
State/Province
North West England
ZIP/Postal Code
L7 8XP
Country
United Kingdom
Facility Name
Royal Surrey Hospital
City
Guildford
State/Province
South East
ZIP/Postal Code
S10 2TB
Country
United Kingdom
Facility Name
Heart of England NHS Foundation Trust, Good Hope Hospital
City
Sutton Coldfield
State/Province
Staffordshire
ZIP/Postal Code
B75 7RR
Country
United Kingdom
Facility Name
University Hospital of Wales
City
Cardiff
State/Province
Wales
ZIP/Postal Code
CF4 4XW
Country
United Kingdom
Facility Name
Bradford Royal Infirmary (BRI)
City
Bradford
State/Province
West Yorkshire
ZIP/Postal Code
BD18 4JN
Country
United Kingdom
Facility Name
Sheffield Teaching Hospitals
City
Sheffield
State/Province
Yorkshire
ZIP/Postal Code
S10 2TB
Country
United Kingdom
Facility Name
Barnet Hospital
City
Barnet
ZIP/Postal Code
EN5 3DJ
Country
United Kingdom
Facility Name
Bristol Eye Hospital
City
Bristol
ZIP/Postal Code
BS1 2LX
Country
United Kingdom
Facility Name
University Hospital Aintree
City
Liverpool
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Facility Name
Moorfields Eye Hospital
City
London
ZIP/Postal Code
EC1V 2PD
Country
United Kingdom
Facility Name
Barnet Royal Free Hospital
City
London
ZIP/Postal Code
EN53DJ
Country
United Kingdom
Facility Name
King's College Hospital
City
London
ZIP/Postal Code
SE5 9RJ
Country
United Kingdom
Facility Name
Royal Victoria Infirmary
City
Newcastle
ZIP/Postal Code
NE1 4LP
Country
United Kingdom
Facility Name
Hospital of St. Cross
City
Rugby
ZIP/Postal Code
CV22 5PX
Country
United Kingdom
Facility Name
City Hospitals Sunderland NHS
City
Sunderland
ZIP/Postal Code
SR2 9HP
Country
United Kingdom

12. IPD Sharing Statement

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Safety and Efficacy of Abicipar Pegol in Participants With Neovascular Age-related Macular Degeneration

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