Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia (RR)
Fever, Febrile Neutropenia
About this trial
This is an interventional treatment trial for Fever focused on measuring Neutropenic fever, extended infusion, beta-lactam, empiric antibiotic treatment
Eligibility Criteria
Inclusion Criteria:
- Patients who are able to sign an informed consent form
Hospitalized patients for one of the following reasons:
- Induction or consolidation for Acute Leukemia
- Patients Hospitalized for Autologous BMT
- Patients Hospitalized for Allogeneic BMT.
Exclusion Criteria:
- Patients under the age of 18.
- Patients who are unable to provide informed consent.
- Patients with acute lymphatic leukemia hospitalized for maintenance treatment
- Patients who will not be staying for the entire duration of neutropenia in house.
Sites / Locations
- Tel-Aviv Sourasky Medicak center / BMT Unit
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Prolonged Infusion of antibiotics
Fixed time infusion of antibiotics
Prolonged (4 hours) Infusion of antibiotics. Intervention: Primary care would be one of three options: Piperacillin/tazobactam : 4.5gr, TID, I.V. Or Fortum (Ceftazidim): 2.0gr, TID, I.V. - for penicillin-sensitive patients. Or Meropenem: 1.0gr, TID, I.V. Supplementation of Vancomycin will be at the discretion of the treating physician.
Fixed time (half and hour) infusion of antibiotics. Intervention: Primary care would be one of three options: Piperacillin/tazobactam : 4.5gr, TID, I.V. Or Fortum (Ceftazidim): 2.0gr, TID, I.V. - for penicillin-sensitive patients. Or Meropenem: 1.0gr, TID, I.V. Supplementation of Vancomycin will be at the discretion of the treating physician/