Prospective, Randomized Study Evaluating The Efficacy of Chlorhexidine Gluconate Impregnated No-Rinse Cloths. (SAGE)
Osteoarthritis, Infection
About this trial
This is an interventional prevention trial for Osteoarthritis focused on measuring infection; arthroplasty; chlorhexidine; hip; knee
Eligibility Criteria
Inclusion Criteria:
- Joint replacement surgery for any reason
- 18 years or older
Exclusion Criteria:
- unable to comply with study requirements
- were pregnant
- were under the age of 18 years
- medical history of immunosuppression or systemic disease e.g. human immunodeficiency virus, status-post organ transplantation
- received greater than 10 milligrams of prednisone equivalent for more than 10 days within 90 days prior to enrollment;
- chronic hepatitis B or C infection
- had an infection in or around the joint requiring surgery.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Sham Comparator
Active Comparator
Active Comparator
Sham Comparator
Sham Comparator
Active Comparator
Sham Comparator
Active Comparator
Primary Control TKA
Primary Treatment TKA
Revision Treatment TKA
Revision Control TKA
Primary Control THA
Primary Treatment THA
Revision Control THA
Revision Treatment THA
Patients undergoing a first or primary total knee arthroplasty will be randomized to the intervention of Standard of care bathing with antibacterial soap and water.
Patients undergoing a first or primary total knee arthroplasty will be randomized to the intervention of chlorhexidine impregnated cloths.
Patients undergoing a second or subsequent or a revision total knee arthroplasty will be randomized to the intervention of a chlorhexidine impregnated cloths.
Patients undergoing a second or revision total knee arthroplasty will be randomized to the intervention of Standard of care bathing with antibacterial soap and water.
Patients undergoing a first or primary total hip arthroplasty will be randomized to the intervention of Standard of care bathing with antibacterial soap and water.
Patients undergoing a first or primary total hip arthroplasty will be randomized to the intervention of chlorhexidine impregnated cloths.
Patients undergoing a second or revision total hip arthroplasty will be randomized to the intervention of Standard of care bathing with antibacterial soap and water.
Patients undergoing a second or subsequent or a revision total knee arthroplasty will be randomized to the intervention of chlorhexidine impregnated cloths.