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An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC) (CheckMate 227)

Primary Purpose

Non-Small Cell Lung Cancer

Status
Active
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Nivolumab
Ipilimumab
Carboplatin
Cisplatin
Gemcitabine
Pemetrexed
Paclitaxel
Sponsored by
Bristol-Myers Squibb
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Non-Small Cell Lung Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Subjects with histologically confirmed Stage IV or recurrent NSCLC squamous or non-squamous histology, with no prior systemic anticancer therapy
  • Subjects must have programmed death-ligand 1 (PD -L1) immunohistochemical (IHC) testing, with results, performed by the central lab during the Screening period
  • Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1
  • Measurable disease by CT or MRI per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) criteria

Exclusion Criteria:

  • Subjects with untreated Central nervous system (CNS) metastases are excluded
  • Subjects with an active, known or suspected autoimmune disease are excluded
  • Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) indicating acute or chronic infection

Other protocol defined inclusion/exclusion criteria apply

Sites / Locations

  • Southern Cancer Center, Inc.
  • California Pacific Medical Center
  • Local Institution - 0021
  • Local Institution - 0001
  • Local Institution - 0013
  • Local Institution - 0004
  • Washington University School Of Medicine
  • Local Institution - 0005
  • Local Institution - 0019
  • University Hospitals
  • Local Institution - 0009
  • Local Institution - 0007
  • St. Mary Medical Center
  • Local Institution - 0299
  • Local Institution - 0012
  • Local Institution - 0015
  • Local Institution - 0008
  • Local Institution - 0080
  • Local Institution - 0010
  • Local Institution - 0020
  • Local Institution - 0306
  • Local Institution - 0003
  • Local Institution - 0102
  • Local Institution - 0011
  • Local Institution - 0074
  • Local Institution - 0170
  • Local Institution - 0171
  • Local Institution - 0172
  • Local Institution - 0176
  • Local Institution - 0296
  • Local Institution - 0177
  • Local Institution - 0130
  • Local Institution - 0268
  • Local Institution - 0297
  • Local Institution - 0272
  • Local Institution - 0182
  • Local Institution - 0301
  • Local Institution - 0300
  • Local Institution - 0183
  • Local Institution - 0045
  • Local Institution - 0046
  • Local Institution - 0043
  • Local Institution - 0042
  • Local Institution - 0180
  • Local Institution - 0040
  • Local Institution - 0241
  • Local Institution - 0240
  • Local Institution - 0239
  • Local Institution - 0121
  • Local Institution - 0030
  • Local Institution - 0031
  • Local Institution - 0034
  • Local Institution - 0117
  • Local Institution - 0033
  • Local Institution - 0125
  • Local Institution - 0124
  • Local Institution - 0123
  • Local Institution - 0127
  • Local Institution - 0129
  • Local Institution - 0144
  • Local Institution - 0126
  • Local Institution - 0128
  • Local Institution - 0103
  • Local Institution - 0290
  • Local Institution - 0104
  • Local Institution - 0122
  • Local Institution - 0106
  • Local Institution - 0107
  • Local Institution - 0291
  • Local Institution - 0292
  • Local Institution - 0302
  • Local Institution - 0173
  • Local Institution - 0131
  • Local Institution - 0174
  • Local Institution - 0380
  • Local Institution - 0313
  • Local Institution - 0315
  • Local Institution - 0316
  • Local Institution - 0314
  • Local Institution - 0365
  • Local Institution - 0364
  • Local Institution - 0378
  • Local Institution - 0322
  • Local Institution - 0372
  • Local Institution - 0319
  • Local Institution - 0325
  • Local Institution - 0324
  • Local Institution - 0379
  • Local Institution - 0375
  • Local Institution - 0362
  • Local Institution - 0347
  • Local Institution - 0329
  • Local Institution - 0361
  • Local Institution - 0359
  • Local Institution - 0371
  • Local Institution - 0333
  • Local Institution - 0360
  • Local Institution - 0334
  • Local Institution - 0376
  • Local Institution - 0373
  • Local Institution - 0340
  • Local Institution - 0343
  • Local Institution - 0370
  • Local Institution - 0342
  • Local Institution - 0328
  • Local Institution - 0323
  • Local Institution - 0341
  • Local Institution - 0345
  • Local Institution - 0336
  • Local Institution - 0337
  • Local Institution - 0374
  • Local Institution - 0273
  • Local Institution - 0237
  • Local Institution - 0238
  • Local Institution - 0282
  • Local Institution - 0112
  • Local Institution - 0113
  • Local Institution - 0111
  • Local Institution - 0232
  • Local Institution - 0270
  • Local Institution - 0271
  • Local Institution - 0222
  • Local Institution - 0216
  • Local Institution - 0229
  • Local Institution - 0283
  • Local Institution - 0218
  • Local Institution - 0228
  • Local Institution - 0215
  • Local Institution - 0230
  • Local Institution - 0227
  • Local Institution - 0223
  • Local Institution - 0225
  • Local Institution - 0221
  • Local Institution - 0217
  • Local Institution - 0224
  • Local Institution - 0226
  • Local Institution - 0231
  • Local Institution - 0213
  • Local Institution - 0208
  • Local Institution - 0205
  • Local Institution - 0210
  • Local Institution - 0211
  • Local Institution - 0203
  • Local Institution - 0209
  • Local Institution - 0202
  • Local Institution - 0214
  • Local Institution - 0206
  • Local Institution - 0204
  • Local Institution - 0201
  • Local Institution - 0212
  • Local Institution - 0094
  • Local Institution - 0095
  • Local Institution - 0190
  • Local Institution - 0101
  • Local Institution - 0025
  • Local Institution - 0024
  • Local Institution - 0026
  • Local Institution - 0054
  • Local Institution - 0053
  • Local Institution - 0055
  • Local Institution - 0100
  • Local Institution - 0187
  • Local Institution - 0186
  • Local Institution - 0185
  • Local Institution - 0184
  • Local Institution - 0188
  • Istituto Europeo di Oncologia IRCCS
  • Azienda Ospedaliera Moscati
  • ASST Papa Giovanni XXIII
  • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
  • Local Institution - 0084
  • Policlinico G. Martino
  • Fondazione IRCCS Istituto Nazionale dei Tumori
  • Istituto Nazionale Tumori Fondazione Pascale
  • S.C. Di Oncologia Medica Azienda Ospedaliera Di Perugia
  • Ospedale Santa Maria delle Croci
  • Ifo-Istituto Regina Elena
  • Local Institution - 0089
  • Ospedale S.Maria
  • Local Institution - 0153
  • Local Institution - 0152
  • Local Institution - 0260
  • Local Institution - 0148
  • Local Institution - 0159
  • Local Institution - 0160
  • Local Institution - 0259
  • Local Institution - 0255
  • Local Institution - 0258
  • Local Institution - 0163
  • Local Institution - 0253
  • Local Institution - 0252
  • Local Institution - 0156
  • Local Institution - 0146
  • Local Institution - 0161
  • Local Institution - 0150
  • Local Institution - 0275
  • Local Institution - 0254
  • Local Institution - 0145
  • Local Institution - 0164
  • Local Institution - 0158
  • Local Institution - 0155
  • Local Institution - 0154
  • Local Institution - 0251
  • Local Institution - 0257
  • Local Institution - 0353
  • Local Institution - 0256
  • Local Institution - 0151
  • Local Institution - 0147
  • Local Institution - 0149
  • Local Institution - 0278
  • Local Institution - 0157
  • Local Institution - 0354
  • Local Institution - 0165
  • Local Institution - 0162
  • Local Institution - 0136
  • Local Institution - 0249
  • Local Institution - 0133
  • Local Institution - 0132
  • Local Institution - 0135
  • Local Institution - 0287
  • Local Institution - 0286
  • Local Institution - 0196
  • Local Institution - 0193
  • Local Institution - 0198
  • Local Institution - 0197
  • Local Institution - 0191
  • Local Institution - 0267
  • Local Institution - 0277
  • Local Institution - 0303
  • Local Institution - 0192
  • Local Institution - 0195
  • Local Institution - 0236
  • Local Institution - 0194
  • Local Institution - 0036
  • Local Institution - 0189
  • Local Institution - 0169
  • Local Institution - 0037
  • Local Institution - 0039
  • Local Institution - 0262
  • Local Institution - 0263
  • Local Institution - 0350
  • Local Institution - 0261
  • Local Institution - 0351
  • Local Institution - 0060
  • Local Institution - 0058
  • Local Institution - 0063
  • Local Institution - 0072
  • Local Institution - 0057
  • Local Institution - 0059
  • Local Institution - 0070
  • Local Institution - 0167
  • Local Institution - 0250
  • Local Institution - 0166
  • Local Institution - 0284
  • Local Institution - 0137
  • Local Institution - 0142
  • Local Institution - 0022
  • Local Institution - 0049
  • Local Institution - 0028
  • Local Institution - 0027
  • Local Institution - 0143
  • Local Institution - 0264
  • Local Institution - 0234
  • Local Institution - 0233
  • Local Institution - 0305
  • Local Institution - 0064
  • Local Institution - 0066
  • Local Institution - 0067
  • Local Institution - 0065
  • Local Institution - 0069
  • Local Institution - 0068
  • Local Institution - 0243
  • Local Institution - 0246
  • Local Institution - 0244
  • Local Institution - 0245
  • Local Institution - 0139
  • Local Institution - 0138
  • Local Institution - 0140
  • Local Institution - 0310
  • Local Institution - 0141
  • Local Institution - 0266
  • Local Institution - 0098
  • Local Institution - 0099
  • Local Institution - 0118
  • Local Institution - 0265
  • Local Institution - 0051
  • Local Institution - 0109
  • Local Institution - 0097
  • Local Institution - 0050
  • Local Institution - 0119

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Experimental

Experimental

Experimental

Experimental

Arm Label

Arm A: Nivolumab

Arm B: Nivolumab + Ipilimumab

Arm C: Nivolumab + Platinum doublet chemotherapy

Arm D: Platinum doublet chemotherapy

Arm Description

Nivolumab intravenously (IV) as specified

Nivolumab + Ipilimumab IV as specified

Nivolumab + Platinum doublet chemotherapy (IV) dose as specified

Chemotherapy administered on specified days of IV chemotherapy

Outcomes

Primary Outcome Measures

Overall survival (OS)
Progression-free Survival (PFS) as determined by blinded independent central review (BICR)

Secondary Outcome Measures

Objective response rate (ORR)
ORR of nivolumab monotherapy and nivolumab in combination with ipilimumab to platinum-doublet chemotherapy in subjects with advanced lung cancer
Disease related symptom improvement as measured by the Lung Cancer Symptom Score (LCSS) in all subjects
Disease related symptom improvement assessed at each dosing for 6 months, then every 6 weeks while on treatment

Full Information

First Posted
June 18, 2015
Last Updated
October 4, 2023
Sponsor
Bristol-Myers Squibb
Collaborators
Ono Pharmaceutical Co. Ltd
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1. Study Identification

Unique Protocol Identification Number
NCT02477826
Brief Title
An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)
Acronym
CheckMate 227
Official Title
An Open-Label, Randomized Phase 3 Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Subjects With Chemotherapy-Naïve Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC)
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Active, not recruiting
Study Start Date
August 5, 2015 (Actual)
Primary Completion Date
August 29, 2024 (Anticipated)
Study Completion Date
August 30, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bristol-Myers Squibb
Collaborators
Ono Pharmaceutical Co. Ltd

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to show that Nivolumab, or Nivolumab plus Ipilimumab, or Nivolumab plus Platinum-Doublet Chemotherapy improves progression free survival and/or overall survival compared with chemotherapy in patients with advanced lung cancer.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-Small Cell Lung Cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2748 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Arm A: Nivolumab
Arm Type
Experimental
Arm Description
Nivolumab intravenously (IV) as specified
Arm Title
Arm B: Nivolumab + Ipilimumab
Arm Type
Experimental
Arm Description
Nivolumab + Ipilimumab IV as specified
Arm Title
Arm C: Nivolumab + Platinum doublet chemotherapy
Arm Type
Experimental
Arm Description
Nivolumab + Platinum doublet chemotherapy (IV) dose as specified
Arm Title
Arm D: Platinum doublet chemotherapy
Arm Type
Experimental
Arm Description
Chemotherapy administered on specified days of IV chemotherapy
Intervention Type
Drug
Intervention Name(s)
Nivolumab
Other Intervention Name(s)
Opdivo
Intervention Type
Drug
Intervention Name(s)
Ipilimumab
Other Intervention Name(s)
Yervoy
Intervention Type
Drug
Intervention Name(s)
Carboplatin
Intervention Type
Drug
Intervention Name(s)
Cisplatin
Intervention Type
Drug
Intervention Name(s)
Gemcitabine
Intervention Type
Drug
Intervention Name(s)
Pemetrexed
Intervention Type
Drug
Intervention Name(s)
Paclitaxel
Primary Outcome Measure Information:
Title
Overall survival (OS)
Time Frame
approximately 48 months
Title
Progression-free Survival (PFS) as determined by blinded independent central review (BICR)
Time Frame
approximately 40 months
Secondary Outcome Measure Information:
Title
Objective response rate (ORR)
Description
ORR of nivolumab monotherapy and nivolumab in combination with ipilimumab to platinum-doublet chemotherapy in subjects with advanced lung cancer
Time Frame
Up to 48 months
Title
Disease related symptom improvement as measured by the Lung Cancer Symptom Score (LCSS) in all subjects
Description
Disease related symptom improvement assessed at each dosing for 6 months, then every 6 weeks while on treatment
Time Frame
Up to 48 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Subjects with histologically confirmed Stage IV or recurrent NSCLC squamous or non-squamous histology, with no prior systemic anticancer therapy Subjects must have programmed death-ligand 1 (PD -L1) immunohistochemical (IHC) testing, with results, performed by the central lab during the Screening period Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1 Measurable disease by CT or MRI per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) criteria Exclusion Criteria: Subjects with untreated Central nervous system (CNS) metastases are excluded Subjects with an active, known or suspected autoimmune disease are excluded Any positive test for hepatitis B virus or hepatitis C virus or human immunodeficiency virus (HIV) indicating acute or chronic infection Other protocol defined inclusion/exclusion criteria apply
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bristol-Myers Squibb
Organizational Affiliation
Bristol-Myers Squibb
Official's Role
Study Director
Facility Information:
Facility Name
Southern Cancer Center, Inc.
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
California Pacific Medical Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Local Institution - 0021
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Local Institution - 0001
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Local Institution - 0013
City
Marietta
State/Province
Georgia
ZIP/Postal Code
30060
Country
United States
Facility Name
Local Institution - 0004
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40503
Country
United States
Facility Name
Washington University School Of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Local Institution - 0005
City
Buffalo
State/Province
New York
ZIP/Postal Code
14263
Country
United States
Facility Name
Local Institution - 0019
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
University Hospitals
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
Local Institution - 0009
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Local Institution - 0007
City
Allentown
State/Province
Pennsylvania
ZIP/Postal Code
18103
Country
United States
Facility Name
St. Mary Medical Center
City
Langhorne
State/Province
Pennsylvania
ZIP/Postal Code
19047
Country
United States
Facility Name
Local Institution - 0299
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Local Institution - 0012
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19111-2412
Country
United States
Facility Name
Local Institution - 0015
City
Sayre
State/Province
Pennsylvania
ZIP/Postal Code
18840
Country
United States
Facility Name
Local Institution - 0008
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Local Institution - 0080
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29605
Country
United States
Facility Name
Local Institution - 0010
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29607
Country
United States
Facility Name
Local Institution - 0020
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Local Institution - 0306
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-8852
Country
United States
Facility Name
Local Institution - 0003
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Local Institution - 0102
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Local Institution - 0011
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84108
Country
United States
Facility Name
Local Institution - 0074
City
Kennewick
State/Province
Washington
ZIP/Postal Code
99336
Country
United States
Facility Name
Local Institution - 0170
City
Berazategui
State/Province
Buenos Aires
ZIP/Postal Code
1880
Country
Argentina
Facility Name
Local Institution - 0171
City
Capital Federal
State/Province
Buenos Aires
ZIP/Postal Code
1426
Country
Argentina
Facility Name
Local Institution - 0172
City
Ciudad Autonoma De Buenos Aire
State/Province
Buenos Aires
ZIP/Postal Code
1181
Country
Argentina
Facility Name
Local Institution - 0176
City
Ciudad de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
1025
Country
Argentina
Facility Name
Local Institution - 0296
City
Mar Del Plata
State/Province
Buenos Aires
ZIP/Postal Code
7600
Country
Argentina
Facility Name
Local Institution - 0177
City
Viedma
State/Province
RIO Negro
ZIP/Postal Code
8500
Country
Argentina
Facility Name
Local Institution - 0130
City
San Miguel de Tucuman
State/Province
Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Local Institution - 0268
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Local Institution - 0297
City
Cordoba
ZIP/Postal Code
X5004FHP
Country
Argentina
Facility Name
Local Institution - 0272
City
Córdoba
ZIP/Postal Code
5016
Country
Argentina
Facility Name
Local Institution - 0182
City
Garran
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Facility Name
Local Institution - 0301
City
Blacktown
State/Province
New South Wales
ZIP/Postal Code
2148
Country
Australia
Facility Name
Local Institution - 0300
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
Facility Name
Local Institution - 0183
City
Tamworth
State/Province
New South Wales
ZIP/Postal Code
2340
Country
Australia
Facility Name
Local Institution - 0045
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Facility Name
Local Institution - 0046
City
Elizabeth Vale
State/Province
South Australia
ZIP/Postal Code
5112
Country
Australia
Facility Name
Local Institution - 0043
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
Local Institution - 0042
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
Local Institution - 0180
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Facility Name
Local Institution - 0040
City
Murdoch
ZIP/Postal Code
6150
Country
Australia
Facility Name
Local Institution - 0241
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Local Institution - 0240
City
Vienna
ZIP/Postal Code
1090
Country
Austria
Facility Name
Local Institution - 0239
City
Wels
ZIP/Postal Code
4600
Country
Austria
Facility Name
Local Institution - 0121
City
Roeselare
State/Province
West-Vlaanderen
ZIP/Postal Code
8800
Country
Belgium
Facility Name
Local Institution - 0030
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Facility Name
Local Institution - 0031
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Local Institution - 0034
City
Gilly
ZIP/Postal Code
6060
Country
Belgium
Facility Name
Local Institution - 0117
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
Facility Name
Local Institution - 0033
City
Sint Niklaas
ZIP/Postal Code
9100
Country
Belgium
Facility Name
Local Institution - 0125
City
Salvador
State/Province
Bahia
ZIP/Postal Code
40170-110
Country
Brazil
Facility Name
Local Institution - 0124
City
Ijui
State/Province
RIO Grande DO SUL
ZIP/Postal Code
98700-000
Country
Brazil
Facility Name
Local Institution - 0123
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90610-000
Country
Brazil
Facility Name
Local Institution - 0127
City
Barretos
State/Province
Sao Paulo
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Local Institution - 0129
City
Rio De Janeiro
ZIP/Postal Code
20231-050
Country
Brazil
Facility Name
Local Institution - 0144
City
Sao Paulo
ZIP/Postal Code
01321-001
Country
Brazil
Facility Name
Local Institution - 0126
City
Sao Paulo
ZIP/Postal Code
01509-010
Country
Brazil
Facility Name
Local Institution - 0128
City
Sao Paulo
ZIP/Postal Code
05403-010
Country
Brazil
Facility Name
Local Institution - 0103
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 1Z2
Country
Canada
Facility Name
Local Institution - 0290
City
St. John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Facility Name
Local Institution - 0104
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5W9
Country
Canada
Facility Name
Local Institution - 0122
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Local Institution - 0106
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1J 1Z4
Country
Canada
Facility Name
Local Institution - 0107
City
Rimouski
State/Province
Quebec
ZIP/Postal Code
G5L 5T1
Country
Canada
Facility Name
Local Institution - 0291
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
Local Institution - 0292
City
Trois-Rivieres
State/Province
Quebec
ZIP/Postal Code
G8Z 3R9
Country
Canada
Facility Name
Local Institution - 0302
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Local Institution - 0173
City
Santiago
State/Province
Metropolitana
ZIP/Postal Code
7500921
Country
Chile
Facility Name
Local Institution - 0131
City
Santiago
State/Province
Metropolitana
ZIP/Postal Code
8420383
Country
Chile
Facility Name
Local Institution - 0174
City
Vina Del Mar
State/Province
Valparaiso
ZIP/Postal Code
254 0364
Country
Chile
Facility Name
Local Institution - 0380
City
Hefei
State/Province
Anhui
ZIP/Postal Code
230001
Country
China
Facility Name
Local Institution - 0313
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100001
Country
China
Facility Name
Local Institution - 0315
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100021
Country
China
Facility Name
Local Institution - 0316
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100021
Country
China
Facility Name
Local Institution - 0314
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100032
Country
China
Facility Name
Local Institution - 0365
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400037
Country
China
Facility Name
Local Institution - 0364
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400038
Country
China
Facility Name
Local Institution - 0378
City
Chongqing
State/Province
Chongqing
ZIP/Postal Code
400042
Country
China
Facility Name
Local Institution - 0322
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510060
Country
China
Facility Name
Local Institution - 0372
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510095
Country
China
Facility Name
Local Institution - 0319
City
Guanzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
Facility Name
Local Institution - 0325
City
Haerbin
State/Province
Heilongjiang
ZIP/Postal Code
150081
Country
China
Facility Name
Local Institution - 0324
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
0
Country
China
Facility Name
Local Institution - 0379
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450052
Country
China
Facility Name
Local Institution - 0375
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430024
Country
China
Facility Name
Local Institution - 0362
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410013
Country
China
Facility Name
Local Institution - 0347
City
Nanchang
State/Province
Jiangxi
ZIP/Postal Code
0
Country
China
Facility Name
Local Institution - 0329
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130012
Country
China
Facility Name
Local Institution - 0361
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130021
Country
China
Facility Name
Local Institution - 0359
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110000
Country
China
Facility Name
Local Institution - 0371
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710061
Country
China
Facility Name
Local Institution - 0333
City
Xi'an
State/Province
Shan3xi
ZIP/Postal Code
710038
Country
China
Facility Name
Local Institution - 0360
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266061
Country
China
Facility Name
Local Institution - 0334
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200032
Country
China
Facility Name
Local Institution - 0376
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Facility Name
Local Institution - 0373
City
Tianjin
State/Province
Tianjin
ZIP/Postal Code
300060
Country
China
Facility Name
Local Institution - 0340
City
Urumqi
State/Province
Xinjiang
ZIP/Postal Code
830011
Country
China
Facility Name
Local Institution - 0343
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
Facility Name
Local Institution - 0370
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310009
Country
China
Facility Name
Local Institution - 0342
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310022
Country
China
Facility Name
Local Institution - 0328
City
Changsha
ZIP/Postal Code
0
Country
China
Facility Name
Local Institution - 0323
City
Haikou
ZIP/Postal Code
570311
Country
China
Facility Name
Local Institution - 0341
City
Hangzhou
ZIP/Postal Code
310016
Country
China
Facility Name
Local Institution - 0345
City
Kunming
ZIP/Postal Code
0
Country
China
Facility Name
Local Institution - 0336
City
Shanghai
ZIP/Postal Code
200030
Country
China
Facility Name
Local Institution - 0337
City
Shanghai
ZIP/Postal Code
200030
Country
China
Facility Name
Local Institution - 0374
City
Shantou
ZIP/Postal Code
0
Country
China
Facility Name
Local Institution - 0273
City
Pereira
State/Province
Risaralda
ZIP/Postal Code
0
Country
Colombia
Facility Name
Local Institution - 0237
City
Bogota
ZIP/Postal Code
0
Country
Colombia
Facility Name
Local Institution - 0238
City
Bogota
ZIP/Postal Code
0
Country
Colombia
Facility Name
Local Institution - 0282
City
Medellin
ZIP/Postal Code
050034
Country
Colombia
Facility Name
Local Institution - 0112
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Local Institution - 0113
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Local Institution - 0111
City
Praha 4
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Local Institution - 0232
City
Pribram
ZIP/Postal Code
261 01
Country
Czechia
Facility Name
Local Institution - 0270
City
Oulu
ZIP/Postal Code
90029
Country
Finland
Facility Name
Local Institution - 0271
City
Turku
ZIP/Postal Code
20520
Country
Finland
Facility Name
Local Institution - 0222
City
Bron
State/Province
Rhône
ZIP/Postal Code
69677
Country
France
Facility Name
Local Institution - 0216
City
ANGERS Cedex 2
ZIP/Postal Code
49055
Country
France
Facility Name
Local Institution - 0229
City
Besançon Cedex
ZIP/Postal Code
0
Country
France
Facility Name
Local Institution - 0283
City
Caen
ZIP/Postal Code
14076
Country
France
Facility Name
Local Institution - 0218
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
Local Institution - 0228
City
Limoges
ZIP/Postal Code
87042
Country
France
Facility Name
Local Institution - 0215
City
Marseille Cedex 20
ZIP/Postal Code
13915
Country
France
Facility Name
Local Institution - 0230
City
Paris
ZIP/Postal Code
75018
Country
France
Facility Name
Local Institution - 0227
City
Pessac
ZIP/Postal Code
33604
Country
France
Facility Name
Local Institution - 0223
City
Rennes
ZIP/Postal Code
350330
Country
France
Facility Name
Local Institution - 0225
City
Rouen Cedex
ZIP/Postal Code
76038
Country
France
Facility Name
Local Institution - 0221
City
Saint Priest En Jarez
ZIP/Postal Code
42271
Country
France
Facility Name
Local Institution - 0217
City
Saint-herblain Cedex
ZIP/Postal Code
44805
Country
France
Facility Name
Local Institution - 0224
City
Strasbourg
ZIP/Postal Code
67000
Country
France
Facility Name
Local Institution - 0226
City
Toulon
ZIP/Postal Code
83056
Country
France
Facility Name
Local Institution - 0231
City
Magdeburg
State/Province
Sachsen-Anhalt
ZIP/Postal Code
39120
Country
Germany
Facility Name
Local Institution - 0213
City
Bad Berka
ZIP/Postal Code
99437
Country
Germany
Facility Name
Local Institution - 0208
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
Local Institution - 0205
City
Essen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Local Institution - 0210
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Facility Name
Local Institution - 0211
City
Gera
ZIP/Postal Code
07548
Country
Germany
Facility Name
Local Institution - 0203
City
Grosshansdorf
ZIP/Postal Code
22927
Country
Germany
Facility Name
Local Institution - 0209
City
Halle
ZIP/Postal Code
06120
Country
Germany
Facility Name
Local Institution - 0202
City
Heidelberg
ZIP/Postal Code
69126
Country
Germany
Facility Name
Local Institution - 0214
City
Hemer
ZIP/Postal Code
58675
Country
Germany
Facility Name
Local Institution - 0206
City
Immenstadt
ZIP/Postal Code
87509
Country
Germany
Facility Name
Local Institution - 0204
City
Muenchen
ZIP/Postal Code
81925
Country
Germany
Facility Name
Local Institution - 0201
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Local Institution - 0212
City
Wiesbaden
ZIP/Postal Code
65199
Country
Germany
Facility Name
Local Institution - 0094
City
Athens
State/Province
Attikí
ZIP/Postal Code
115 27
Country
Greece
Facility Name
Local Institution - 0095
City
Heraklion
ZIP/Postal Code
711 10
Country
Greece
Facility Name
Local Institution - 0190
City
Neo Faliro
ZIP/Postal Code
18547
Country
Greece
Facility Name
Local Institution - 0101
City
Thessaloniki
ZIP/Postal Code
54007
Country
Greece
Facility Name
Local Institution - 0025
City
Budapest
ZIP/Postal Code
1083
Country
Hungary
Facility Name
Local Institution - 0024
City
Budapest
ZIP/Postal Code
1121
Country
Hungary
Facility Name
Local Institution - 0026
City
Matrahaza
ZIP/Postal Code
3233
Country
Hungary
Facility Name
Local Institution - 0054
City
Dublin 8
State/Province
Dublin
Country
Ireland
Facility Name
Local Institution - 0053
City
Dublin
ZIP/Postal Code
9
Country
Ireland
Facility Name
Local Institution - 0055
City
Galway
ZIP/Postal Code
0
Country
Ireland
Facility Name
Local Institution - 0100
City
Limerick
ZIP/Postal Code
0
Country
Ireland
Facility Name
Local Institution - 0187
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Local Institution - 0186
City
Kfar-saba
ZIP/Postal Code
44281
Country
Israel
Facility Name
Local Institution - 0185
City
Petach Tikva
ZIP/Postal Code
49100
Country
Israel
Facility Name
Local Institution - 0184
City
Tel-hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Local Institution - 0188
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
Facility Name
Istituto Europeo di Oncologia IRCCS
City
Milan
State/Province
Lombardia
ZIP/Postal Code
20141
Country
Italy
Facility Name
Azienda Ospedaliera Moscati
City
Avellino
ZIP/Postal Code
83024
Country
Italy
Facility Name
ASST Papa Giovanni XXIII
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Facility Name
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Local Institution - 0084
City
Livorno
ZIP/Postal Code
57124
Country
Italy
Facility Name
Policlinico G. Martino
City
Messina
ZIP/Postal Code
98125
Country
Italy
Facility Name
Fondazione IRCCS Istituto Nazionale dei Tumori
City
Milan
ZIP/Postal Code
20133
Country
Italy
Facility Name
Istituto Nazionale Tumori Fondazione Pascale
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
S.C. Di Oncologia Medica Azienda Ospedaliera Di Perugia
City
Perugia
ZIP/Postal Code
06132
Country
Italy
Facility Name
Ospedale Santa Maria delle Croci
City
Ravenna
ZIP/Postal Code
48121
Country
Italy
Facility Name
Ifo-Istituto Regina Elena
City
Roma
ZIP/Postal Code
00144
Country
Italy
Facility Name
Local Institution - 0089
City
Roma
ZIP/Postal Code
00161
Country
Italy
Facility Name
Ospedale S.Maria
City
Terni
ZIP/Postal Code
05100
Country
Italy
Facility Name
Local Institution - 0153
City
Nagoya-shi
State/Province
Aichi
ZIP/Postal Code
4600001
Country
Japan
Facility Name
Local Institution - 0152
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
4648681
Country
Japan
Facility Name
Local Institution - 0260
City
Chiba-shi
State/Province
Chiba
ZIP/Postal Code
2608677
Country
Japan
Facility Name
Local Institution - 0148
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
2778577
Country
Japan
Facility Name
Local Institution - 0159
City
Matsuyama
State/Province
Ehime
ZIP/Postal Code
791-0280
Country
Japan
Facility Name
Local Institution - 0160
City
Fukuoka-shi
State/Province
Fukuoka
ZIP/Postal Code
8120054
Country
Japan
Facility Name
Local Institution - 0259
City
Kurume-shi
State/Province
Fukuoka
ZIP/Postal Code
8300011
Country
Japan
Facility Name
Local Institution - 0255
City
Ota-shi
State/Province
Gunma
ZIP/Postal Code
3730828
Country
Japan
Facility Name
Local Institution - 0258
City
Hiroshima-shi
State/Province
Hiroshima
ZIP/Postal Code
7308518
Country
Japan
Facility Name
Local Institution - 0163
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
0030804
Country
Japan
Facility Name
Local Institution - 0253
City
Sapporo-shi
State/Province
Hokkaido
ZIP/Postal Code
0608648
Country
Japan
Facility Name
Local Institution - 0252
City
Akashi-shi
State/Province
Hyogo
ZIP/Postal Code
6738558
Country
Japan
Facility Name
Local Institution - 0156
City
Kobe-shi
State/Province
Hyogo
ZIP/Postal Code
6500047
Country
Japan
Facility Name
Local Institution - 0146
City
Kanazawa-shi
State/Province
Ishikawa
ZIP/Postal Code
9208641
Country
Japan
Facility Name
Local Institution - 0161
City
Yokohama-shi
State/Province
Kanagawa
ZIP/Postal Code
2210855
Country
Japan
Facility Name
Local Institution - 0150
City
Yokohama-Shi
State/Province
Kanagawa
ZIP/Postal Code
2360051
Country
Japan
Facility Name
Local Institution - 0275
City
Natori-shi
State/Province
Miyagi
ZIP/Postal Code
9811293
Country
Japan
Facility Name
Local Institution - 0254
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
9800873
Country
Japan
Facility Name
Local Institution - 0145
City
Sendai-shi
State/Province
Miyagi
ZIP/Postal Code
9808574
Country
Japan
Facility Name
Local Institution - 0164
City
Niigata-shi
State/Province
Niigata
ZIP/Postal Code
9518566
Country
Japan
Facility Name
Local Institution - 0158
City
Kurashiki-shi
State/Province
Okayama
ZIP/Postal Code
7100052
Country
Japan
Facility Name
Local Institution - 0155
City
Hirakata-shi
State/Province
Osaka
ZIP/Postal Code
5731191
Country
Japan
Facility Name
Local Institution - 0154
City
Osaka-shi
State/Province
Osaka
ZIP/Postal Code
5340021
Country
Japan
Facility Name
Local Institution - 0251
City
Osakasayama-shi
State/Province
Osaka
ZIP/Postal Code
5890014
Country
Japan
Facility Name
Local Institution - 0257
City
Takatsuki-shi
State/Province
Osaka
ZIP/Postal Code
5698686
Country
Japan
Facility Name
Local Institution - 0353
City
Hidaka-shi
State/Province
Saitama
ZIP/Postal Code
3501298
Country
Japan
Facility Name
Local Institution - 0256
City
Kitaadachi-gun
State/Province
Saitama
ZIP/Postal Code
3620806
Country
Japan
Facility Name
Local Institution - 0151
City
Sunto-gun
State/Province
Shizuoka
ZIP/Postal Code
4118777
Country
Japan
Facility Name
Local Institution - 0147
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
1040045
Country
Japan
Facility Name
Local Institution - 0149
City
Koto-ku
State/Province
Tokyo
ZIP/Postal Code
1358550
Country
Japan
Facility Name
Local Institution - 0278
City
Shinjuku-ku
State/Province
Tokyo
ZIP/Postal Code
1600023
Country
Japan
Facility Name
Local Institution - 0157
City
Wakayama-shi
State/Province
Wakayama
ZIP/Postal Code
641-8510
Country
Japan
Facility Name
Local Institution - 0354
City
Ube-shi
State/Province
Yamaguchi
ZIP/Postal Code
7550241
Country
Japan
Facility Name
Local Institution - 0165
City
Okayama
ZIP/Postal Code
700-8558
Country
Japan
Facility Name
Local Institution - 0162
City
Tokyo
ZIP/Postal Code
113-8603
Country
Japan
Facility Name
Local Institution - 0136
City
Seongnam-si
State/Province
Kyǒnggi-do
ZIP/Postal Code
436-707
Country
Korea, Republic of
Facility Name
Local Institution - 0249
City
Cheongju-si
ZIP/Postal Code
28644
Country
Korea, Republic of
Facility Name
Local Institution - 0133
City
Gangnam-gu
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Local Institution - 0132
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Local Institution - 0135
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
Local Institution - 0287
City
Beirut
ZIP/Postal Code
00961
Country
Lebanon
Facility Name
Local Institution - 0286
City
Beirut
ZIP/Postal Code
166830
Country
Lebanon
Facility Name
Local Institution - 0196
City
Df
State/Province
Distrito Federal
ZIP/Postal Code
06720
Country
Mexico
Facility Name
Local Institution - 0193
City
Mexico
State/Province
Distrito Federal
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Local Institution - 0198
City
Cuautitlan
State/Province
Estado DE Mexico
ZIP/Postal Code
54769
Country
Mexico
Facility Name
Local Institution - 0197
City
Guadalajara
State/Province
Jalisco
ZIP/Postal Code
44270
Country
Mexico
Facility Name
Local Institution - 0191
City
Zapopan
State/Province
Jalisco
ZIP/Postal Code
44280
Country
Mexico
Facility Name
Local Institution - 0267
City
Morelia
State/Province
Michoacan
ZIP/Postal Code
58000
Country
Mexico
Facility Name
Local Institution - 0277
City
Monterrey
State/Province
Nuevo Leon
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Local Institution - 0303
City
Merida
State/Province
Yucatán
ZIP/Postal Code
97070
Country
Mexico
Facility Name
Local Institution - 0192
City
Chihuahua
ZIP/Postal Code
31217
Country
Mexico
Facility Name
Local Institution - 0195
City
San Luis Potosi
ZIP/Postal Code
78200
Country
Mexico
Facility Name
Local Institution - 0236
City
San Luis Potosi
ZIP/Postal Code
78213
Country
Mexico
Facility Name
Local Institution - 0194
City
Toluca
ZIP/Postal Code
50180
Country
Mexico
Facility Name
Local Institution - 0036
City
Amsterdam
ZIP/Postal Code
1066 CX
Country
Netherlands
Facility Name
Local Institution - 0189
City
Amsterdam
ZIP/Postal Code
1081 HV
Country
Netherlands
Facility Name
Local Institution - 0169
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
Facility Name
Local Institution - 0037
City
Rotterdam
ZIP/Postal Code
3014 GD
Country
Netherlands
Facility Name
Local Institution - 0039
City
Veldhoven
ZIP/Postal Code
5504 DB
Country
Netherlands
Facility Name
Local Institution - 0262
City
Lima
ZIP/Postal Code
0
Country
Peru
Facility Name
Local Institution - 0263
City
Lima
ZIP/Postal Code
0
Country
Peru
Facility Name
Local Institution - 0350
City
Lima
ZIP/Postal Code
27
Country
Peru
Facility Name
Local Institution - 0261
City
Lima
ZIP/Postal Code
34
Country
Peru
Facility Name
Local Institution - 0351
City
Lima
ZIP/Postal Code
Lima 41
Country
Peru
Facility Name
Local Institution - 0060
City
Bydgoszcz
ZIP/Postal Code
85-796
Country
Poland
Facility Name
Local Institution - 0058
City
Gdansk
ZIP/Postal Code
80-19
Country
Poland
Facility Name
Local Institution - 0063
City
Gdynia
ZIP/Postal Code
81-519
Country
Poland
Facility Name
Local Institution - 0072
City
Gliwice
ZIP/Postal Code
44-101
Country
Poland
Facility Name
Local Institution - 0057
City
Lodz
ZIP/Postal Code
93-513
Country
Poland
Facility Name
Local Institution - 0059
City
Warszawa
ZIP/Postal Code
02-781
Country
Poland
Facility Name
Local Institution - 0070
City
Wroclaw
ZIP/Postal Code
52-229
Country
Poland
Facility Name
Local Institution - 0167
City
Craiova
ZIP/Postal Code
200542
Country
Romania
Facility Name
Local Institution - 0250
City
Floresti
ZIP/Postal Code
407280
Country
Romania
Facility Name
Local Institution - 0166
City
Romania
ZIP/Postal Code
400015
Country
Romania
Facility Name
Local Institution - 0284
City
Sector 2
ZIP/Postal Code
022328
Country
Romania
Facility Name
Local Institution - 0137
City
Chelyabinsk
ZIP/Postal Code
454048
Country
Russian Federation
Facility Name
Local Institution - 0142
City
Kazan
ZIP/Postal Code
420029
Country
Russian Federation
Facility Name
Local Institution - 0022
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Local Institution - 0049
City
Saint-Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Local Institution - 0028
City
St. Petersburg
ZIP/Postal Code
194291
Country
Russian Federation
Facility Name
Local Institution - 0027
City
St. Petersburg
ZIP/Postal Code
198255
Country
Russian Federation
Facility Name
Local Institution - 0143
City
Ufa
ZIP/Postal Code
450054
Country
Russian Federation
Facility Name
Local Institution - 0264
City
Pretoria
State/Province
Gauteng
ZIP/Postal Code
0002
Country
South Africa
Facility Name
Local Institution - 0234
City
Sandton
State/Province
Gauteng
ZIP/Postal Code
2196
Country
South Africa
Facility Name
Local Institution - 0233
City
Saxonwold, Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2196
Country
South Africa
Facility Name
Local Institution - 0305
City
Vereeniging
ZIP/Postal Code
1936
Country
South Africa
Facility Name
Local Institution - 0064
City
Majadahonda
State/Province
Madrid
ZIP/Postal Code
28222
Country
Spain
Facility Name
Local Institution - 0066
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Local Institution - 0067
City
Barcelona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Local Institution - 0065
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Local Institution - 0069
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Local Institution - 0068
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Local Institution - 0243
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Local Institution - 0246
City
Chur
ZIP/Postal Code
7000
Country
Switzerland
Facility Name
Local Institution - 0244
City
Lausanne
ZIP/Postal Code
1011
Country
Switzerland
Facility Name
Local Institution - 0245
City
Winterthur
ZIP/Postal Code
8401
Country
Switzerland
Facility Name
Local Institution - 0139
City
Taichung
ZIP/Postal Code
407
Country
Taiwan
Facility Name
Local Institution - 0138
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Local Institution - 0140
City
Taipei
ZIP/Postal Code
112
Country
Taiwan
Facility Name
Local Institution - 0310
City
Taipei
ZIP/Postal Code
235
Country
Taiwan
Facility Name
Local Institution - 0141
City
Taoyuan city
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Local Institution - 0266
City
Middlesborough
State/Province
Cleveland
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Facility Name
Local Institution - 0098
City
London
State/Province
Greater London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Facility Name
Local Institution - 0099
City
Southampton
State/Province
Hampshire
ZIP/Postal Code
SO16 0YD
Country
United Kingdom
Facility Name
Local Institution - 0118
City
Leicester
State/Province
Leicestershire
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
Local Institution - 0265
City
Birmingham
ZIP/Postal Code
B4 6DHH
Country
United Kingdom
Facility Name
Local Institution - 0051
City
Cambridgeshire
ZIP/Postal Code
CB2 2QQ
Country
United Kingdom
Facility Name
Local Institution - 0109
City
Edinburgh
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Facility Name
Local Institution - 0097
City
London
ZIP/Postal Code
N18 1QX
Country
United Kingdom
Facility Name
Local Institution - 0050
City
London
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Facility Name
Local Institution - 0119
City
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
33485960
Citation
Reck M, Ciuleanu TE, Lee JS, Schenker M, Audigier-Valette C, Zurawski B, Linardou H, Otterson GA, Salman P, Nishio M, de la Mora Jimenez E, Lesniewski-Kmak K, Albert I, Ahmed S, Syrigos K, Penrod JR, Yuan Y, Blum SI, Nathan FE, Sun X, Moreno-Koehler A, Taylor F, O'Byrne KJ. First-Line Nivolumab Plus Ipilimumab Versus Chemotherapy in Advanced NSCLC With 1% or Greater Tumor PD-L1 Expression: Patient-Reported Outcomes From CheckMate 227 Part 1. J Thorac Oncol. 2021 Apr;16(4):665-676. doi: 10.1016/j.jtho.2020.12.019. Epub 2021 Jan 21.
Results Reference
derived
PubMed Identifier
31562796
Citation
Hellmann MD, Paz-Ares L, Bernabe Caro R, Zurawski B, Kim SW, Carcereny Costa E, Park K, Alexandru A, Lupinacci L, de la Mora Jimenez E, Sakai H, Albert I, Vergnenegre A, Peters S, Syrigos K, Barlesi F, Reck M, Borghaei H, Brahmer JR, O'Byrne KJ, Geese WJ, Bhagavatheeswaran P, Rabindran SK, Kasinathan RS, Nathan FE, Ramalingam SS. Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer. N Engl J Med. 2019 Nov 21;381(21):2020-2031. doi: 10.1056/NEJMoa1910231. Epub 2019 Sep 28.
Results Reference
derived
PubMed Identifier
31195357
Citation
Reck M, Schenker M, Lee KH, Provencio M, Nishio M, Lesniewski-Kmak K, Sangha R, Ahmed S, Raimbourg J, Feeney K, Corre R, Franke FA, Richardet E, Penrod JR, Yuan Y, Nathan FE, Bhagavatheeswaran P, DeRosa M, Taylor F, Lawrance R, Brahmer J. Nivolumab plus ipilimumab versus chemotherapy as first-line treatment in advanced non-small-cell lung cancer with high tumour mutational burden: patient-reported outcomes results from the randomised, open-label, phase III CheckMate 227 trial. Eur J Cancer. 2019 Jul;116:137-147. doi: 10.1016/j.ejca.2019.05.008. Epub 2019 Jun 11.
Results Reference
derived
PubMed Identifier
29658845
Citation
Hellmann MD, Ciuleanu TE, Pluzanski A, Lee JS, Otterson GA, Audigier-Valette C, Minenza E, Linardou H, Burgers S, Salman P, Borghaei H, Ramalingam SS, Brahmer J, Reck M, O'Byrne KJ, Geese WJ, Green G, Chang H, Szustakowski J, Bhagavatheeswaran P, Healey D, Fu Y, Nathan F, Paz-Ares L. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018 May 31;378(22):2093-2104. doi: 10.1056/NEJMoa1801946. Epub 2018 Apr 16.
Results Reference
derived
Links:
URL
https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Description
BMS Clinical Trial Information
URL
https://www.bmsstudyconnect.com/s/US/English/USenHome
Description
BMS Clinical Trial Patient Recruiting
URL
https://www.fda.gov/Safety/MedWatch/SafetyInformation/default.htm
Description
FDA Safety Alerts and Recalls

Learn more about this trial

An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC)

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