Effects of High vs. Standard Protein Intake in Newborn Extreme Premature (experimental)
Abnormal Renal Function, Malnutrition
About this trial
This is an interventional prevention trial for Abnormal Renal Function focused on measuring amino acids, renal function, extreme premature
Eligibility Criteria
Inclusion Criteria:
1. Preterm infant of less than 32 gestational weeks and weighting less than 1500g
Exclusion Criteria:
- Preterm infant with severe congenital malformations.
- Patients with acute kidney failure.
- Inform consent form not signed.
Sites / Locations
- Instituto Mexicano del Seguro Social
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
use amine acids parenteral 3.5g
use amine acids parenteral 4g
Amino acids parenteral (Levamin Nomo 10% ®) Group A with an initial doses of amino acids until reaching 3.5 g/kg/day during 28 days.For the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA. The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.
Group B with an initial doses of 2.5 g/kg/day with daily increments of 0.5 g/kg/day until reaching 4 g/kg/day during 34 days.Weight, urea, creatinine and blood urea nitrogen (BUN) were measured weeklyFor the study of renal function baseline urea, creatinine and BUN were measured within 24 h after birth in order to avoid any alteration cost by mother alter kidney function, afterwards the same markers were measured at the day 7, 14, 21 and 28. These markers were measure using orto-clinical diagnostic series 50-0278 USA. The anthropometric measurements were assessed weekly by the same person to avoid bias (cephalic perimeter and height); weight was measured weekly using the same scale (SECA model 3741321009, Germany). All anthropometric and lab results were kept in a collection sheet.