Predetermination for Gingival Recession
Primary Purpose
Gingival Recessions
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Coronally advanced flap with connective tissue graft
Sponsored by
About this trial
This is an interventional diagnostic trial for Gingival Recessions focused on measuring prognostic factors
Eligibility Criteria
Inclusion Criteria:
- Presence of isolated RT1 and RT2 class gingival recessions with an AERSA ˃9mm2 on upper and lower incisors,
- Presence of identifiable cemento-enamel junction (CEJ); presence of a step ≤1mm at the CEJ level and/or the presence of a root abrasion, but with an identifiable CEJ,
- Full-mouth plaque score and Full-mouth bleeding score of <15%,
- No occlusal interferences;
Exclusion Criteria:
Exclusion criteria were:
- Patients with a history of periodontitis or abscess formation,
- Mucogingival or periodontal surgery at the experimental site in the last 1 year,
- Presence of systemic disease or taking medication known to interfere with periodontal tissue health,
- Smokers, pregnant patients.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm Type
Other
Other
Arm Label
gingival recession type 1
gingival recession type 2
Arm Description
recession defects without CAL intervention:Coronally advanced flap with connective tissue graft
gingival recession with an amount of CAL equal or smaller to the buccal CAL. Intervention: Coronally advanced flap with connective tissue graft
Outcomes
Primary Outcome Measures
values of baseline interdental papill height
in mm
Secondary Outcome Measures
avascular exposed root surface area
.n mm2
interdental clinical attachment level
in mm
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02479633
Brief Title
Predetermination for Gingival Recession
Official Title
Predetermınatıon of Root Coverage for Recessıons Treated wıth Coronally Advanced Flap wıth Connectıve Tissue Graft: An Exploratıve Study
Study Type
Interventional
2. Study Status
Record Verification Date
June 2015
Overall Recruitment Status
Completed
Study Start Date
January 2013 (undefined)
Primary Completion Date
January 2014 (Actual)
Study Completion Date
June 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Cukurova University
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Background: The aim of present clinical study was to evaluate the predictive values of baseline inter-dental papilla height (IPH), avascular exposed root surface area (AERSA) and inter-dental clinical attachment loss (CAL) measurements on complete root coverage (CRC) of single gingival recession (GR) defects treated with coronally advanced flap and connective tissue graft technique (CAF+CTG).
Material and Methods: The study group included 65 females and 57 males, aged between 20 and 42 years. A total of 122 recession defects without CAL and with an amount of CAL equal or smaller to the buccal CAL , located at upper and lower incisors and canines were treated with CAF+CTG. IPH, AERSA and CAL parameters were analyzed for possible correlation with CRC after 6 months.
Detailed Description
The coronally advanced flap (CAF) with connective tissue graft (CTG) has been confirmed as the gold standard for treatment of gingival recessions ). CTG-based procedures provide the best outcomes with superior percentages of mean root coverage (MRC) and complete root coverage (CRC) and keratinized tissue (KT) gain. Data in previous reports show CRC range from 18% to 83% after CAF+CTG in Miller Classes I and II defects which are associated with no inter-dental clinical attachment loss (interdental-CAL) (Recession Type 1-RT1)
The use of CTG under CAF significantly enhances the probability to achieve CRC (%57) in recessions in which interdental-CAL is equal or smaller than the buccal attachment loss (Recession Type 2-RT2). It has been emphasized that CRC percentage was very similar to the result (60%) of a multicentre study on the treatment of RT1 recessions (Cortellini et al. 2009). Moreover, CRC was higher than most of the reports on treatment of RT1 or Miller I and II defects (more than 80%) when baseline interdental-CAL was between 1 and 3 mm Therefore, various CRC outcomes of the literature indicate that there is need for additional defect defining criteria for predicting the outcomes of root coverage (RC) in RT 1 and RT2 (interdental-CAL≤ 3mm) recession defects.
Predetermination of final RC which is important for distinguishing 'expected versus actual' amount of RC was found to be related to inter-dental papilla height (IPH) and inter-dental clinical attachment level (ICAL) by the clinical studies which reported correlation between these two anatomical characteristics and CRC. Recently a new predictive classification of gingival recessions using the baseline avascular exposed root surface area (AERSA) as an identification criterion has been proposed. AERSA resulted as a strong predictor of final RC after laterally positioned flap (LPF) leading to a prognostic model with AERSA explaining 86% of the mean root coverage. In addition, due to anatomic variations, some Miller Class I defects may have larger AERSA than Miller Class II and III defects or there may be smaller Miller Class III defects than Miller Class I and II defects which may significantly influence the treatment results. These results could help to explain the outcome variations among previous studies.
The prognostic anticipation of a certain amount of RC is a complex process including patient-related, tooth/site-related (GRD, root abrasion, ICAL, tooth type, the dimension of inter-dental papilla, AERSA) and technique-related (e.g. quality of the CTG) factors and operator's skill. It is essential to define the most potent prognostic factors' combination which can increase the success and predictability rates, to make CAF+CTG the most convenient RC technique for patients and clinicians. Therefore the aim of this study was to explore the predictive values of baseline IPH, AERSA and ICAL measurements on the final RC outcomes after CAF+CTG in RT1 and RT2 class GR defects.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Gingival Recessions
Keywords
prognostic factors
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
Investigator
Allocation
Non-Randomized
Enrollment
122 (Actual)
8. Arms, Groups, and Interventions
Arm Title
gingival recession type 1
Arm Type
Other
Arm Description
recession defects without CAL intervention:Coronally advanced flap with connective tissue graft
Arm Title
gingival recession type 2
Arm Type
Other
Arm Description
gingival recession with an amount of CAL equal or smaller to the buccal CAL. Intervention: Coronally advanced flap with connective tissue graft
Intervention Type
Other
Intervention Name(s)
Coronally advanced flap with connective tissue graft
Other Intervention Name(s)
CAF+CTG
Intervention Description
Two oblique, divergent releasing incisions extending beyond the mucogingival junction were performed. An intra-sulcular incision was performed at the buccal aspect of the involved tooth. Subsequently, a partial-thickness flap was raised beyond the MGJ. The papilla adjacent to the involved tooth were then de-epithelialized.
The CTG was harvested using a single incision approach from the palate. The graft was positioned on the instrumented root surface immediately apical of the CEJ and then stabilized using a sling compressive crossing suture. The flap was coronally displaced 1-2 mm above the CEJ. A sling suture was placed to stabilize the flap in a coronal position, followed by interrupted sutures on the releasing incisions with an apico-coronal direction.
Primary Outcome Measure Information:
Title
values of baseline interdental papill height
Description
in mm
Time Frame
1 year
Secondary Outcome Measure Information:
Title
avascular exposed root surface area
Description
.n mm2
Time Frame
1 year
Title
interdental clinical attachment level
Description
in mm
Time Frame
1 year
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
42 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Presence of isolated RT1 and RT2 class gingival recessions with an AERSA ˃9mm2 on upper and lower incisors,
Presence of identifiable cemento-enamel junction (CEJ); presence of a step ≤1mm at the CEJ level and/or the presence of a root abrasion, but with an identifiable CEJ,
Full-mouth plaque score and Full-mouth bleeding score of <15%,
No occlusal interferences;
Exclusion Criteria:
Exclusion criteria were:
Patients with a history of periodontitis or abscess formation,
Mucogingival or periodontal surgery at the experimental site in the last 1 year,
Presence of systemic disease or taking medication known to interfere with periodontal tissue health,
Smokers, pregnant patients.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Onur Ozcelik, Prof. Dr
Organizational Affiliation
Professor
Official's Role
Principal Investigator
12. IPD Sharing Statement
Learn more about this trial
Predetermination for Gingival Recession
We'll reach out to this number within 24 hrs