Finnish Unicompartmental and Total Knee Arthroplasty Investigation (FUNCTION)
Osteoarthritis, Knee
About this trial
This is an interventional treatment trial for Osteoarthritis, Knee focused on measuring Total, Unicondylar, Osteoarthritis, Arthroplasty, Replacement, Knee
Eligibility Criteria
Inclusion Criteria:
- Symptomatic medial knee OA with exposed bone on both femur and tibia.
- Age 45 to 79.
- Failed conservative treatment of knee OA.
- Mechanical axis 5 to 15 degrees varus.
- Functionally intact anterior cruciate ligament.
- Full thickness lateral cartilage present
- Correctable intra-articular varus deformity in knee 20 degrees flexion
- American Society of Anesthesiologists Physical Status Classification System (ASA) of 1, 2 or 3.
Exclusion Criteria:
- Rheumatoid arthritis or, other inflammatory disorders.
- Osteonecrosis
- Osteochondritis dissecans
- Symptomatic hip or spinal pathology
- Previous knee surgery other than diagnostic arthroscopy and medial menisectomy
- Previously had infectious arthritis
- Have significant damage to the patella-femoral joint especially on the lateral facet, patellar subluxation or concave patella.
- Previous ligament injury and instability
- Range of movement not within 15-100 degrees.
- Patient is planned to undergo simultaneous bilateral knee arthroplasty.
Sites / Locations
- Central Finland Central Hospital
- Oulu University Hospital
- Turku University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Total Knee Replacement
Unicondylar Knee Replacement
TKA is performed through a standard medial parapatellar incision, which provides easy access to the knee joint. Skin incision is done to midline. Intramedullary guide is used for alignment of femoral and tibia saw cuts and component positions. Components will be cemented in position. The patella will not be resurfaced. Intraoperative local infiltration analgesia (LIA) is used for postoperative pain management. Drain is not used.
UKA involves only the replacement of affected medial compartment. In the study, the operation will be performed through standard medial parapatellar incision with midline skin incision, but the knee joint and fascia will be opened like in standard Oxford minimally invasive incision. The procedure will be performed by using Oxford Microplasty instrumentation and following Microplasty surgical technique (Biomet Orthopedics). Intraoperative local infiltration analgesia is used for postoperative pain management. Drain is not used.