Mannitol Cream for Post Herpetic Neuralgia (MannitolPHN)
Neuralgia, Postherpetic
About this trial
This is an interventional treatment trial for Neuralgia, Postherpetic focused on measuring Mannitol, cream, neuropathic pain
Eligibility Criteria
Inclusion Criteria
- - Suffering from post-herpetic neuralgia on the trunk or the extremities for at least three months.
- - Maximum daily pain score greater than or equal to 5/10.
- - Having failed to improve with at least one neuropathic pain medication.
4- Able and willing to fill a fluid survey NRS pain scale and a medication intake questionnaire daily, preferably online but on paper, if unable, for the first 24 days of the study, then once a month for three months..
5 - Preferably have access to someone who can apply cream to their back if they have pain in the back and cannot reach the area.
6 - If that is not possible, ability to apply the cream to their own back, using an applicator which will be supplied.
Exclusion Criteria:
- Allergies to any of the ingredients of the cream
- Open lesions or abrasions on the skin where the cream will be applied
- Using corticosteroids
- Unwilling to stop using other topical products (creams or patches) for the treatment of post-herpetic neuralgia
- Pregnant, breast-feeding or not using birth control
Suffering from severe chronic pain from a cause other than post-herpetic neuralgia
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Sites / Locations
- Dr. Helene Bertrand Inc.
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
mannitol in vehicle cream /vehicle cream
vehicle cream /mannitol in vehicle cream
one week on the mannitol cream (mannitol 30% in vehicle cream), a 3 day washout period, and one week on the placebo cream (vehicle cream alone). To be applied over the painful area as needed for pain. Usual frequency is 2 to 3 times daily.
one week on the placebo cream (vehicle cream alone), a 3 day washout period, and one week on the mannitol cream (mannitol 30% in vehicle cream).To be applied over the painful area as needed for pain. Usual frequency is unknown.