The Best Dosage and Timing of Polyethylene Glycol for Bowel Preparation Before Capsule Endoscopy
Small Bowel Disease

About this trial
This is an interventional other trial for Small Bowel Disease focused on measuring capsule endoscopy, polyethylene glycol, bowel preparation solutions
Eligibility Criteria
Inclusion Criteria:
- Patients aged between 18 and 75 years and referred to capsule endoscopy because of suspected small-bowel disease are prospectively eligible for entry into the study.
Exclusion Criteria:
- Age < 18 or > 75 years
- Known or suspected GI stricture or fistula
- A history of GI tract resection
- Swallowing disorders
- Intensive therapy with fasting and parenteral nutrition;with a disease that may reduce movement of the GI tract, such as diabetes mellitus
- Medications that could affect gastrointestinal movement within one week
- Implanted with a medical electronic device
- Active inflammatory bowel disease, toxic megacolon, toxic colitis
- Severe pulmonary, cardiac, renal, or hepatic disease
- Uncontrolled hypertension (systolic blood pressure>170 mm Hg, diastolic blood pressure>100 mm Hg);
- Disturbance of electrolytes
- Pregnancy or lactation
- Patients inability to provide written voluntary informed consent
- Participation in another clinical study
Sites / Locations
- Huashan Hospital
- Tongren Hospital Affiliated to Shanghai Jiaotong University, China
- Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Group A
Group B
Group C
Group D
Group E
Fast for 12h before the examination and take 8ml of Simethicone Emulsion (Berlin-Chemie, Germany, containing 40 mg simethicone in 1mL emulsion) with 250ml water 30min before capsule ingestion.CE are performed with the Pillcam SB2 capsule endoscopy system (Given Imaging Co. Ltd., Yoqnem, Israel).
the same as protocol A plus 1L Polyethylene glycol 11-12h before VCE. CE are performed with the Pillcam SB2 capsule endoscopy system.
the same as protocol A plus 2L Polyethylene glycol 10-12h before VCE. CE are performed with the Pillcam SB2 capsule endoscopy system.
Group D: the same as protocol A plus 1L Polyethylene glycol 3-4h before VCE. CE are performed with the Pillcam SB2 capsule endoscopy system.
Group E: the same as protocol A plus 2L Polyethylene glycol 2-4h before VCE. CE are performed with the Pillcam SB2 capsule endoscopy system.