Knowing and Remembering: Cognitive and Neural Influences of Familiarity on Recognition Memory in Early Alzheimer's Disease (EPMR-MA)
Alzheimer's Disease
About this trial
This is an interventional other trial for Alzheimer's Disease focused on measuring Alzheimer, Recognition Memory, Mild Cognitive Impairment, fMRI
Eligibility Criteria
Inclusion Criteria:
Volunteers (pilot phase)
- Aged 25 - 75
- French native speakers
- Right-handed
- Education level equal or superior to primary school leaving certificate
- Free from any medical or psychiatric condition that may impact cognition
- Having given written informed consent
Volunteers (experimental phase)
- Aged 60 - 75
- French native speakers
- Right-handed
- Education level equal or superior to primary school leaving certificate
- Free from any medical or psychiatric condition that may impact cognition
- Having given written informed consent
AD-MCI participants
- Aged 60 - 75
- French native speakers
- Right-handed
- Education level equal or superior to primary school leaving certificate
- Fulfilling criteria for " AD-MCI " (Albert et al., 2011)
- Have been seen in a memory medical center or in Memory Resources and Research Medical Center for cognitive symptoms
- Free from any medical or psychiatric condition that may impact cognition
- Able to understand and consent
- Having given written informed consent
Exclusion Criteria:
MRI contraindications (all participants)
- Claustrophobia
Wearing of any metal implant such as:
- Heart pacemaker
- Iron-magnetic surgical clips
- Any metallic foreign body in the eye or brain
Other criteria (all participants)
- Significant history of neurological or psychiatric disorders
- Ongoing medication that may affect cognitive performances
- Sensory deficit that may interfere with the experimental design (e.g. uncorrected visual impairment)
- Lack of sufficient cooperation during the cognitive tasks
- Persons under major legal protection and/or deprived of liberty
Other criteria (control participants)
- Global cognitive impairment attested by Mattis Dementia Rating Scale or Mini-Mental State Examination, according to available normative data
Other criteria (AD-MCI participants)
- 7 items modified Hachinski ischemic score > 2 (Hachinski et al., 2012)
- Dementia (McKahn, et al., 2011)
Sites / Locations
- Centre Hospitalier Universitaire
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Experimental
Experimental
Healthy volunteers
Patients with early Alzheimer disease
Old healthy volunteers
60 old healthy volunteers (aged 25-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: Neuropsychological tests Experimental procedure
20 patients (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: Neuropsychological tests Experimental procedure A cranial MRI
20 healthy volunteers (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed: Neuropsychological tests Experimental procedure A cranial MRI