Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor, Tremor
About this trial
This is an interventional other trial for Essential Tremor focused on measuring Essential Tremor, Magnetic Resonance Imaging, Therapy, Alcohol, Propranolol
Eligibility Criteria
Inclusion Criteria:
- Diagnosed with ET by a Movement Disorder Neurologist.
- Tremors that improve with alcohol.
- Ability to abstain from drinking alcohol or caffeine for at least 2 days before both the screening and fMRI visits
- Over the age of 21.
Exclusion Criteria:
- Significant non-ET related abnormal findings during neurological exam.
- Presence of a tremor at rest.
- Pregnant or nursing.
- Unable to safely undergo MRI based on completion of a safety questionnaire.
- History of dementia, brain tumor, stroke, head trauma or a vascular malformation based on history or MRI findings.
- Severe active medical condition, such as cardiovascular disease, that prevents subject from lying flat for up to 120 minutes.
- Unable or unwilling to provide informed consent.
- Claustrophobia (a fear of tight spaces) or other restrictions that prevent subject from undergoing an MRI in a confined space for up to 120 minutes.
- Unable to temporarily stop taking medications that may influence liver metabolism or brain function.
- Tremors so severe that subject cannot safely and effectively undergo MRI
- Past/current problems with alcohol abuse or dependence.
- Unwillingness to take alcohol (ethanol), which is a potentially intoxicating drug
- History of deep brain stimulation or thalamotomy surgery.
- Sinus bradycardia, bronchial asthma, or a known allergy to propranolol (Inderal).
Sites / Locations
- University of California, San Diego
Arms of the Study
Arm 1
Arm 2
Other
No Intervention
Essential Tremor Group
Health Volunteer Group
Patients will be randomized to start in one of two treatment arms: 1) 50ml of 40% ethanol or 2) Propranolol SR 60-120mg. In patients who receive ethanol first, they will return for a second visit when they will receive Propranolol, and vice versa. Ethanol will be administered to participants diagnosed with Essential Tremor during the study visit, whereas patients receiving Propranolol SR will be administered daily over an estimated period of two weeks prior to the fMRI visit.
Healthy Volunteers will receive no interventions.