Study of Hypertrophic Cardiomyopathy Under Stress Conditions. Concordance Between Two Complementary Tests: Stress MRI and Exercice Stress Echocardiography (CMHStress)
Hypertrophic Cardiomyopathy
About this trial
This is an interventional diagnostic trial for Hypertrophic Cardiomyopathy focused on measuring Hypertrophic cardiomyopathy, Stress MRI, Cardiac MRI, Stress echocardiography, T1 mapping, 2D strain
Eligibility Criteria
Inclusion Criteria:
- The patient is adult (> or = 18 years) and informed.
- He's agree for a 24-month follow-up.
- The patient must be member or beneficiary of a health insurance system.
- He must have a clear diagnosis of HCM defined by a left ventricular hypertrophy in tranthoracic echocardiography (superior to 15mm or 13mm if there is a familial history) without other causes of hypertrophy (severe hypertension, aortic stenosis, amyloidosis or fabry disease, ..)
Exclusion Criteria:
- The patient is under safeguarding justice, tutorship or curatorship.
- The patient formalizes his opposition.
- It's impossible to give enlightened information.
- The patient doesn't read French.
- The patient is pregnant or breastfeeding.
- Contraindication to the realization of a MRI (defibrillator, no-MRI compatible PMK, claustrophobia,..)
- Contraindication to the Persantine° injection (asthma, high degree block, ..)
- Contraindication or impossibility to realize a stress echocardiography.
- Comorbidity that can be responsible of the studied anomalies: coronaropathy, myomectomy, multicomplicated diabetes, …
Sites / Locations
- Hôpital Arnaud de Villeneuve - CHRU de Montpellier
Arms of the Study
Arm 1
Other
Diagnosis examens
Cardiac MRI: is usually recommended in the diagnosis or in the follow-up of the disease. The MRI will respect the standard protocol: cineMRI sequences, perfusion sequences, LGE sequences at 10 minutes after gadolinium injection. The investigators will realize some additional sequences: T1 mapping before and after gadolinium injection to study the diffuse fibrosis and stress perfusion sequences after injection of a vasodilatator (Persantine°). Exercice stress echocardiography: is realized almost systematically in all the diagnosis of HCM and it's very informative. The investigators will research left ventricular dysfunction: in particular segmentary hypokinesia and anomalies of deformation parameters (2D Strain) and the development of a dynamic left ventricular outflow obstruction or a mitral regurgitation at exercice.