Subcutaneous Wound Infiltration of Ketamine or Bupivacaine Pain Perception After Cesarean Section
Postoperative Pain
About this trial
This is an interventional supportive care trial for Postoperative Pain focused on measuring Caesarean Section
Eligibility Criteria
Inclusion Criteria:
- singleton term pregnancy,
- between 38-41th weeks of gestation,
- absence of any medical or obstetrical problems.
Exclusion Criteria:
- multiple pregnancies,
- intrauterine fetal deaths,
- active stage of labor,
- obstetric emergencies such as antepartum hemorrhage, eclampsia and acute fetal distress,
- special request for general anesthesia,
- history of allergic reaction or sensitivity to any of the drugs used in the study,
- reflected anxiety and depression during the cesarean operation,
- any systemic diseases (chronic hypertension, thyroid diseases, renal or hepatic insufficiency, psychiatric disorders,
- chronic pain syndrome, epilepsy or intracranial hypertension)
- medications that would affect the perception of pain,
- current or past history of narcotic use or a history of narcotic abuse,
- inability to understand how to score a 10-cm visual analogue scale (VAS) for pain.
Sites / Locations
- Kayseri Educational and Research Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Placebo Comparator
Group 1, Ketamine
Group 2, Bupivacaine
Group 3, Ketamine+Bupivacaine
Group 4, Placebo
Ketamine, 1 mg/kg (Ketalar®, 10 mL inj., 50 mg ketamine hydrochloride/ml, Pfizer Drug Company, USA) was administered subcutaneously before the closure of pfannenstiel incision.
Bupivacaine 0.5% 20 mL (100 mg) (Marcaine®, 20 mL inj. 5 mg bupivacaine hydrochloride/ml, AstraZeneca Drug Company, Turkey) was administered subcutaneously before the closure of pfannenstiel incision.
Ketamine 1 mg/kg (Ketalar®) and bupivacaine 0.5% (100 mg) (Marcaine®) were administered subcutaneously before the closure of pfannenstiel incision.
Placebo (0.9% saline solution) was administered subcutaneously before the closure of pfannenstiel incision.