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A Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis

Primary Purpose

Spontaneous Bacterial Peritonitis

Status
Terminated
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Standard Care
Experimental
Sponsored by
NYU Langone Health
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Spontaneous Bacterial Peritonitis

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Age 18 to 75
  • Evidence of end stage liver disease / cirrhosis
  • Documented SBP (ANC > 250 or positive ascites culture
  • Ability to provide informed consent
  • Serum Creatinine > 1.0 mg/dL and/or Total Bilirubin > 4.0 mg/dL

Exclusion Criteria:

  • Nonportal hypertensive ascites (i.e. malignancy)

Sites / Locations

  • NYU Langone Medical Center

Arms of the Study

Arm 1

Arm 2

Arm Type

Placebo Comparator

Experimental

Arm Label

Active Comparator Standard Care

Experimental

Arm Description

albumin administered day 1 (1.5g/kg) and day 3 (1.0g/kg)

Albumin administered per standard care on day 1 (1.5g/kg). Second dose administered on day 2 only to those individuals with renal insufficiency and risk for renal failure (Cr > 1.0 or BUN or Cr > baseline). If albumin not administered at 48 hours, BUN and Cr will be monitored daily for 72 hours and will be administered if Cr > 1.0 or BUN or Cr are above baseline.

Outcomes

Primary Outcome Measures

Renal Failure
Primary outcome is the presence of renal failure at any point from the start of the study (time 0) through 72 hours

Secondary Outcome Measures

All Cause Mortality

Full Information

First Posted
April 4, 2014
Last Updated
May 26, 2016
Sponsor
NYU Langone Health
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1. Study Identification

Unique Protocol Identification Number
NCT02528097
Brief Title
A Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis
Official Title
A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis
Study Type
Interventional

2. Study Status

Record Verification Date
May 2016
Overall Recruitment Status
Terminated
Study Start Date
September 2010 (undefined)
Primary Completion Date
January 2015 (Actual)
Study Completion Date
January 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
NYU Langone Health

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Spontaneous bacterial peritonitis (SBP) is a common and frequently fatal complication of end-stage liver disease with a mortality of up to 10% primarily due to the development of kidney failure. Current standard practice is to treat this infection with broad spectrum antibiotics and salt-poor albumin administration on day one and three of treatment. In this study the investigators test the hypothesis that the administration of a second dose of albumin at 48 hours only to patients with renal insufficiency is as effective at preventing kidney failure as administering the second dose to all patients at 72 hours. In addition, a kidney function determined approach to albumin dosing may lead to substantial cost and resource saving from decreased albumin use without compromising treatment efficacy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Spontaneous Bacterial Peritonitis

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Active Comparator Standard Care
Arm Type
Placebo Comparator
Arm Description
albumin administered day 1 (1.5g/kg) and day 3 (1.0g/kg)
Arm Title
Experimental
Arm Type
Experimental
Arm Description
Albumin administered per standard care on day 1 (1.5g/kg). Second dose administered on day 2 only to those individuals with renal insufficiency and risk for renal failure (Cr > 1.0 or BUN or Cr > baseline). If albumin not administered at 48 hours, BUN and Cr will be monitored daily for 72 hours and will be administered if Cr > 1.0 or BUN or Cr are above baseline.
Intervention Type
Drug
Intervention Name(s)
Standard Care
Intervention Description
Standard Care: 25% salt poor albumin administered day 1 (1.5g/kg) and day 3 (1.0g/kg)
Intervention Type
Drug
Intervention Name(s)
Experimental
Intervention Description
25% salt poor albumin administered per standard care on day 1 (1.5g/kg). Second dose administered on day 2 or later only to those individuals with renal insufficiency and risk for renal failure (Cr > 1.0 or BUN or Cr > baseline)
Primary Outcome Measure Information:
Title
Renal Failure
Description
Primary outcome is the presence of renal failure at any point from the start of the study (time 0) through 72 hours
Time Frame
At any point from time 0 through day 3
Secondary Outcome Measure Information:
Title
All Cause Mortality
Time Frame
At any point from time 0 through day 3
Other Pre-specified Outcome Measures:
Title
Administration of Albumin
Description
The amount of albumin administered to each study participant over the course of the study (time 0 through 72 hours)
Time Frame
Throughout Study (72 hours)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age 18 to 75 Evidence of end stage liver disease / cirrhosis Documented SBP (ANC > 250 or positive ascites culture Ability to provide informed consent Serum Creatinine > 1.0 mg/dL and/or Total Bilirubin > 4.0 mg/dL Exclusion Criteria: Nonportal hypertensive ascites (i.e. malignancy)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Samuel Sigal
Organizational Affiliation
NYU MEDICAL CENTER
Official's Role
Principal Investigator
Facility Information:
Facility Name
NYU Langone Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States

12. IPD Sharing Statement

Learn more about this trial

A Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis

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