Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events (DREPASOM)

Hypothesis is that the occurrence of nocturnal Vaso-Occlusive Crisis (VOC) and priapism in adults might be related to episodes of nocturnal desaturation secondary to a sleep apnea syndrome. Investigator hypothesize that chronic biological consequences of Obstructive Sleep Apnea (hypercoagulability, endothelial dysfunction ...) favour VOC and acute manifestations (nocturnal desaturation) favour nocturnal VOC. The confirmation of this hypothesis will lead investigator to propose a systematic screening of obstructive sleep apnea (OSA) in patients with nocturnal VOC. Moreover, systematic treatment of OSA in sickle cell patients could help significantly reduce the number and severity of nocturnal VOC.

Blood collection is a specific intervention of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " Diurnal VOC " and " Slightly symptomatic "

Minimum oxygen saturation level during rapid eye movement (REM) sleep in patients with recurrent priapism and in patients who never presented priapism

Inclusion Criteria: Night VOC Group: night VOC ≥ 2 in the previous year written informed consent Daytime VOC Group: VOC no nocturnal diurnal VOC ≥ 2 in the previous year written informed consent Slightly symptomatic group: no hospitalization for VOC written informed consent Exclusion Criteria: Taking opioids Taking medication that alters sleep (antidepressants, benzodiazepines ...) Known history of sleep apnea syndrome Known history of serious psychiatric disorder Recent vaso-occlusive crisis (within 3 weeks) Changes in background treatment (Hydrea or exchange transfusions) in the past 12 months Inactive affiliation to social security Under legal protection A female who is pregnant or breastfeeding Prisoners Emergency situation Refusing to participate in the study

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