Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD (HeartBeet)
Peripheral Arterial Disease
About this trial
This is an interventional treatment trial for Peripheral Arterial Disease focused on measuring Dietary nitrate supplementation, Beetroot juice
Eligibility Criteria
Inclusion Criteria:
- Patients with peripheral arterial disease (PAD)
- Capable of giving informed consent
- Men and women age 21- 85 years
- Diagnosed with PAD (i.e., ankle-brachial index below 0.9)
- Fontaine stage II or less - no pain while resting
- Satisfactory history and physical exam
Exclusion Criteria:
- Children
- Pregnant or nursing women
- Patients taking nitroglycerine or nitrate preparations
- Patients taking phosphodiesterase inhibitors such as sildenafil or tadalafil
- Patients taking proton pump inhibitors
- Ejection fraction < 40%
- Uncontrolled hypertension
- Uncontrolled diabetes
- Myocardial infarction within past 6 months or unstable angina
- Severe lung disease (i.e., on supplemental oxygen or frequently use rescue inhalers)
- Abnormality in hemoglobin or hematocrit or methemoglobin
- Impaired renal function
- Impaired liver function
- History or diagnosis of Barrett's esophagus
- Known allergy to beetroot juice or lemon juice
- Inability to walk on a treadmill at a moderate pace (2.0 miles/hour)
Sites / Locations
- Milton S. Hershey Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Beetroot juice (Beet-It Organic Shot)
Beetroot juice placebo (Beet-It Organic Placebo)
Subjects will consume 70 ml of beetroot juice (Beet-It Organic Shot) twice per day (morning, afternoon) for 5 to 7 days to assess the short term effects of this nitrate supplement on graded treadmill walking responses (day 4) and vasodilator/vasoconstrictor responses in the coronary and lower leg circulations (day 5 or 6 or 7). On both study visits, subjects will consume their morning dose 1 hour 45 min before experiments begin.
Subjects will consume 70 ml of beetroot juice placebo (Beet-It Organic Placebo) twice per day (morning, afternoon) for 5 to 7 days to assess the short term effects of this nitrate supplement on graded treadmill walking responses (day 4) and vasodilator/vasoconstrictor responses in the coronary and lower leg circulations (day 5 or 6 or 7). On both study visits, subjects will consume their morning dose 1 hour 45 min before experiments begin.