Cross-linking for Corneal Ulcers Treatment Trial (CLAIR)
Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer
About this trial
This is an interventional treatment trial for Corneal Ulcer focused on measuring Cornea, Ulcer, Infectious keratitis, Bacterial, Fungal
Eligibility Criteria
Inclusion criteria:
- Corneal ulcer that is smear positive for either bacteria or filamentous fungus
- Pinhole visual acuity worse than 20/70 in the affected eye
- Not treated already with antimicrobial medications at presentation
- Age over 18 years
- Basic understanding of the study as determined by the physician
- Commitment to return for follow up visits
Exclusion criteria:
- Evidence of concomitant infection on exam or gram stain (i.e. herpes, both bacteria and acanthamoeba on gram stain)
- Impending or frank perforation at recruitment
- Involvement of sclera at presentation
- Non-infectious or autoimmune keratitis
- History of corneal transplantation or recent intraocular surgery
- No light perception in the affected eye
- Pinhole visual acuity worse than 20/200 in the unaffected eye
- Participants who are decisionally and/or cognitively impaired
Sites / Locations
- Proctor Foundation, UCSF
- Aravind Eye HospitalsRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Active Comparator
Experimental
Active Comparator
Experimental
Active Comparator
Bacterial ulcer cross-linking
Bacterial ulcer control
Fungal ulcer cross-linking plus natamycin
Fungal ulcer control with natamycin
Fungal ulcer cross-linking plus amphotericin
Fungal ulcer control with amphotericin
Standard of care topical treatment for bacterial ulcer plus cross-linking
Standard of care topical treatment for bacterial ulcer
Standard of care topical treatment for fungal ulcer with natamycin plus cross-linking
Standard of care topical treatment for fungal ulcer with natamycin
Standard of care topical treatment for fungal ulcer with amphotericin plus cross-linking
Standard of care topical treatment for fungal ulcer with amphotericin