A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC) (CheckMate370)
Non-Small Cell Lung Cancer

About this trial
This is an interventional treatment trial for Non-Small Cell Lung Cancer
Eligibility Criteria
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com
Inclusion Criteria:
- Histologically confirmed locally advanced or stage IV NSCLC
- Eastern Cooperative Oncology Group (ECOG) Performance status (PS) 0-2
- Tumor tissue sections must be available for biomarker evaluation
Exclusion Criteria:
- Untreated or active/progressing Central Nervous system (CNS) metastases
- Active, known or suspected autoimmune disease
- Known history of testing positive for HIV or AIDS
- Active or chronic infection of hepatitis B virus or hepatitis C
Sites / Locations
- Alabama Oncology
- Southern Cancer Center Pc
- Arizona Oncology Assoc, Pc-Hal
- Northern Arizona Hematology & Oncology Associates
- Arizona Oncol Assoc Dba (Hem Onc Physicians&Extenders) Hope
- Arizona Clinical Research Center, Inc.
- Comprehensive Blood And Cancer Center
- St. Joseph Heritage Medical Group
- Scripps Cancer Center
- UCLA Hematology/Oncology Clinic
- Coastal Integrative Cancer Care
- Central Coast Med Oncology
- Local Institution
- St. Mary's Hospital Regional Cancer Center
- Rocky Mountain Cancer Centers
- Eastern Ct Hem Onc Assoc
- Stamford Hospital
- Va Ct Healthcare System
- Florida Cancer Specialists S.
- University of Florida at Shands
- Memorial Cancer Institute
- Baptist Health Medical Group Oncology
- Ocala Oncology Center
- Hematology Oncology Associates Of The Treasure Coast
- Florida Cancer Specialists
- Tallahassee Memorial Cancer Center
- Florida Cancer Affiliates
- University Cancer Blood Ctr
- Cancer Treatment Centers Of America
- Summit Cancer Care
- Lewis Hall Singletary Oncology Center
- Illinois Cancer Specialists
- Community Clinical Research Center
- Ft. Wayne Med Onco-Hema Inc
- Cotton-O-Neil Clinical Research Center
- West KY Hematology Oncology Group PSC
- Christus St. Francis Cabrini Cancer Center
- East Jefferson General Hospital
- New England Cancer Specialists
- Anne Arundel Medical Center
- University Of Maryland
- Sinai Hospital Of Baltimore
- Center For Cancer And Blood Disorders
- Maryland Oncology Hematology, P.A.
- Bay Hematology Oncology
- Cancer & Hematology Centers Of Western Michigan
- Minnesota Oncology Hematology, P.A.
- Forrest General Cancer Center
- Jackson Oncology Associates, Pllc
- St. Louis Cancer Care, Llp
- Saint Vincent Frontier Cancer Center
- Southeast Nebraska Cancer Center
- Nebraska Cancer Specialists
- Comprehensive Cancer Centers of Nevada
- Hunterdon Medical Center
- Summit Medical Group
- Atlantic Health System
- Morristown Medical Center
- San Juan Oncology Associates
- New York Oncology Hematology, Pc
- Glens Falls Hospital
- Broome Oncology
- Northern Westchester Hospital
- Columbia University Medical Center (Cumc)
- Hematology-Oncology Associates Of Rockland
- White Plains Hospital
- Cone Health Cancer Center
- Moses Cone Health System
- Randolph Cancer Center
- First Health Of The Carolinas
- W.G. Bill Hefner VA Medical Center
- Cancer Care Center
- Sanford Health
- Oncology Hematology Care, Inc.
- Louis Stokes Cleveland VA Medical Center
- MetroHealth Medical Center
- Mid Ohio Oncology Hematology
- Oklahoma Cancer Specialists and Research Institute, LLC-Clinical Research
- Oncology Associates Of Oregon, Pc
- Hematology Oncology Associates
- Lehigh Valley Hospital
- St. Luke's University Hospital Bethlehem
- Erie Regional Cancer Center
- Abington Hematology Oncology Associates, Inc
- Charleston Hematology Oncology Associates, Pa
- Greenville Health System
- Sanford Research
- Chattanooga Oncology Hematology Associates
- The Jones Clinic, PC
- West Cancer Center
- Tennessee Oncology, PLLC - SCRI - PPDS
- Texas Oncology-Abilene
- Texas Oncology - Amarillo
- Texas Oncology-Arlington North
- Texas Oncology-Central Austin Cancer Center
- Texas Oncology-Beaumont
- Texas Oncology
- Texas Oncology/Methodist Charlton Cancer Ctr
- Texas Oncology
- Texas Oncology
- Texas Oncology, P.A.
- Texas Oncology
- Texas Oncology
- Texas Oncology
- Brooke Army Medical Center
- Texas Oncology
- The Center For Cancer And Blood Disorders
- Texas Oncology
- MD Anderson Cancer Center
- Texas Cancer Center Of Mesquite
- Texas Oncology, Pa
- Texas Oncology
- Texas Oncology
- Texas Oncology-Plano East
- Texas Oncology Plano West Cancer Center
- Cancer Centers of South Texas
- Texas Cancer Center - Sherman
- Texas Oncology Cancer Center - Sugar Land
- Texas Oncology-Tyler
- Texas Oncology Cancer Care And Research Center
- Texas Oncology, P.A.
- Texas Oncology
- Texas Oncology-Wichita Falls
- Oncology & Hematology Associates Of Southwest Virginia, Inc.
- Virginia Cancer Specialists, Pc
- Virginia Oncology Associates
- Virginia Cancer Institute
- Shenandoah Oncology
- Providence Regional Cancer Partnership
- Cancer Care Northwest
- Northwest Cancer Specialists, Pc
- Yakima Valley Memorial Hospital/North Star Lodge
- Edwards Comprehensive Cancer Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Experimental
Experimental
Active Comparator
Experimental
Other
Active Comparator
Experimental
Active Comparator
Experimental
Experimental
Group A Nivolumab
Group A Nivolumab + SOC maintenance therapy
Group A SOC maintenance therapy
Group B Nivolumab
Group B Best supportive care
Group C Investigator's choice chemotherapy
Group C Nivolumb
Group D Erlotinib
Group D Nivolumab + Erlotinib
Group E Nivolumab + Crizotinib
Opdivo specified dose on specified days
Opdivo/Bevacizumab specified dose on specified days Opdivo/Pemetrexed specified dose on specified days
Bevacizumab specified dose on specified days Pemetrexed specified dose on specified days
Opdivo specified dose on specified days
Therapy directed against specific symptoms of disease, i.e., palliative radiation or palliative surgery
Carboplatin/nab-paclitaxel specified dose on specified days Carboplatin/paclitaxel specified dose on specified days Carboplatin/pemetrexed specified dose on specified days Carboplatin/docetaxel specified dose on specified days Carboplatin/gemcitabine specified dose on specified days Paclitaxel specified dose on specified days Docetaxel specified dose on specified days Gemcitabine specified dose on specified days Pemetrexed specified dose on specified days
Opdivo specified dose on specified days
Erlotinib specified dose on specified days
Opdivo/Erlotnib specified dose on specified days
Opdivo/Crizotinib specified dose on specified days