Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty: The OCTAVIA Trial (OCTAVIA)
Acute Myocardial Infarction
About this trial
This is an interventional treatment trial for Acute Myocardial Infarction focused on measuring ST segment Elevation Myocardial Infarction, Optical Coherence Tomography, Percutaneous Coronary Intervention, Thrombus histopathology, Gender differences
Eligibility Criteria
Inclusion Criteria:
- Acute Myocardial MI with ST segment Elevation, within 6 hours from symptoms onset
- Native coronary artery disease (no prior stent implant, no prior brachytherapy)
- Signed patient informed consent
Exclusion Criteria:
- Patients with left main disease
- infarct lesions in bypass grafts
- cardiogenic shock
- renal failure
- recent major bleeding
- allergy to aspirin or clopidogrel
- on anticoagulant therapy
- no suitable anatomy for OCT (extreme tortuousity, very distal culprit lesion, and large infarct vessel > 4 mm in diameter)
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Female Arm
Male Arm
Female gender diagnosed with ST segment Elevation Myocardial Infarction (STEMI). Interventions: Angiography, thrombus aspiration, optical coherence tomography and percutaneous coronary intervention, implantation of XIENCE PRIME Everolimus Eluting Coronary Stent. Angiography and Optical Coherence Tomography follow up at 9 months.
Male Gender with diagnose of ST segment Elevation Acute Myocardial Infarction (STEMI). Interventions: Angiography, thrombus aspiration, optical coherence tomography and percutaneous coronary intervention, implantation of XIENCE PRIME Everolimus Eluting Coronary Stent. Angiography and Optical Coherence Tomography follow up at 9 months.