Whey Protein Supplement in Combination With Physical Exercise and Nutrition Program

Influence of a Specially Formulated Whey Protein Supplement in Combination With Physical Exercise and Nutrition Program on Physical Performance in Cancer Outpatients

This study evaluates physical performance in cancer outpatients during a multimodal therapy. Half of the patients will receive physical exercise und nutrition program in combination with a specially formulated whey protein supplement, while the other half will receive standard care.

The time period of Intervention will last 3 month, measurements will be conducted at baseline and 3 month. After 6 month there will be an additional follow-up test point to assess the sustainability of the intervention. The 3-month intervention study consists of a physical exercise program and nutrition counseling in combination with a specially formulated whey protein supplement high in leucine. The standardized training program will be performed twice a week in the physical department of the Kantonsspital Winterthur (KSW) and once a week in a home based setting. Additionally, participants of the intervention group will be aks to consume 15 g of the nutrient supplement powder with approximately 150 ml water. On workout days the supplement should be taken twice a day and on the remaining days once a day. During the three month intervention study participants will take part in a nutrition counseling for at least three times.

Lung Cancer, Gastro-Intestinal Cancer, Breast Cancer, Prostate Cancer, Pleural Mesothelioma, Urothelial Carcinoma, Renal Cell Carcinoma, Ovarian Cancer

Participants will receive physical exercise, nutrition counseling and a whey protein Supplement over 12 weeks

The standardized Training program will be performed twice a week in the Kantonsspital Winterthur and once a week in a home based setting

At least 3 times, participants will receive nutrition counseling to improve energy- and protein intake

On workout days study participants will consume twice a day 15 g of the supplement powder with approximately 150 ml water. On the remaining days participants consume the supplement once a day.

Nutritional status will be assessed with hand grip, nutritional risk screening 2002 and patient-generated subjective global assessment

Inclusion Criteria: Advanced cancer patients not eligible for curative treatment: lung cancer, gastrointestinal cancer, breast cancer, prostate cancer, ovarian cancer, pleural mesothelioma, urothelium carcinoma, renal cell carcinoma WHO performance status ≥ 2 Able to walk independently at least 100 meters Estimated life expectancy of ≥ 6 month Exclusion Criteria: Patients currently using nutritional supplements with branched chain amino acids Enteral or parenteral nutrition within 1 month History of ileus within 1 month Psychiatric disorder precluding understanding of information on trials related topics and giving informed consent Milk protein allergy