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Cognitive Ability Training in Seniors (CATS)

Primary Purpose

Mild Cognitive Impairment

Status
Completed
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
Verum tDCS
Sham tDCS
Sponsored by
Wuerzburg University Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Mild Cognitive Impairment focused on measuring Subjective Memory Impairment, tDCS, NIRS, Cognitive Training, Working Memory

Eligibility Criteria

60 Years - 70 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • native german speaker
  • between 60-70 years old
  • subjective memory impairment

Exclusion Criteria:

  • psychiatric, neurological diseases
  • uncorrected hearing or vision deficits
  • actual psychopharmaca intake
  • metal parts in the head
  • medical electronical implants

Sites / Locations

  • University hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Experimental

Arm Label

Verum tDCS

Sham tDCS

Arm Description

Left frontal anodal stimulation, supraorbital right cathodal stimulation

sham stimulation, same electrode positions

Outcomes

Primary Outcome Measures

Neuropsychological performance in neuropsychological tests
The Investigators are measuring cognitive performance for different executive functions

Secondary Outcome Measures

Brain activation measured with NIRS
The Investigators are measuring brain activation during executive functions

Full Information

First Posted
June 16, 2015
Last Updated
April 9, 2018
Sponsor
Wuerzburg University Hospital
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1. Study Identification

Unique Protocol Identification Number
NCT02587338
Brief Title
Cognitive Ability Training in Seniors
Acronym
CATS
Official Title
Verbesserung Kognitiver Fähigkeiten im Alter
Study Type
Interventional

2. Study Status

Record Verification Date
April 2018
Overall Recruitment Status
Completed
Study Start Date
May 2015 (Actual)
Primary Completion Date
April 2017 (Actual)
Study Completion Date
December 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Wuerzburg University Hospital

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
This study investigates the beneficial effects of prefrontal brain stimulation (with transcranial direct current stimulation [tDCS]) during working memory training in seniors with subjective memory impairments.The placebo-controlled double blinded study includes 50 elderly probants which were randomized into verum or sham tDCS.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Mild Cognitive Impairment
Keywords
Subjective Memory Impairment, tDCS, NIRS, Cognitive Training, Working Memory

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
50 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Verum tDCS
Arm Type
Experimental
Arm Description
Left frontal anodal stimulation, supraorbital right cathodal stimulation
Arm Title
Sham tDCS
Arm Type
Experimental
Arm Description
sham stimulation, same electrode positions
Intervention Type
Device
Intervention Name(s)
Verum tDCS
Intervention Description
Neuropsychological (Working memory) training for 30 minutes, 6 sessions tDCS during training with 2000 microampere left anadal, right cathodal
Intervention Type
Device
Intervention Name(s)
Sham tDCS
Intervention Description
Neuropsychological (Working memory) training for 30 minutes, 6 sessions tDCS during training with 0 microampere
Primary Outcome Measure Information:
Title
Neuropsychological performance in neuropsychological tests
Description
The Investigators are measuring cognitive performance for different executive functions
Time Frame
4 weeks
Secondary Outcome Measure Information:
Title
Brain activation measured with NIRS
Description
The Investigators are measuring brain activation during executive functions
Time Frame
4 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
60 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: native german speaker between 60-70 years old subjective memory impairment Exclusion Criteria: psychiatric, neurological diseases uncorrected hearing or vision deficits actual psychopharmaca intake metal parts in the head medical electronical implants
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Martin J. Herrmann, PD Dr
Organizational Affiliation
University of Würzburg
Official's Role
Principal Investigator
Facility Information:
Facility Name
University hospital
City
Wuerzburg
ZIP/Postal Code
97080
Country
Germany

12. IPD Sharing Statement

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Cognitive Ability Training in Seniors

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