A Trial to Determine the Feasibility and Effectiveness of Early Multisensory Stimulation Intervention in Patients in the Trauma-Neurosurgical Intensive Care Unit (TNICU) Following Severe Acquired Brain Injury
Traumatic Brain Injury With Prolonged Loss of Consciousness
About this trial
This is an interventional treatment trial for Traumatic Brain Injury With Prolonged Loss of Consciousness focused on measuring multisensory stimulation
Eligibility Criteria
Inclusion Criteria:
- At least 2 weeks post injury, no more than 8 weeks post injury
- Glasgow Coma Scale score of less than or equal to 9, or motor component score of 5 or less if patient intubated
- No previous brain injury
- No chronic/progressive neurological illness
- No intracranial pressure monitor
- No more than1 pre-existing sensory impairment (e.g. deafness, blindness)
- Functional level of English for patient and Substitute Decision Maker (i.e. conversational English, work/education in English, completion of English as a Second Language course, etc.)
- Deemed medically appropriate as per Nurse Practitioner/MD (e.g. no active seizures, no sedation, haemodynamically stable, etc.)
Exclusion Criteria: Patients who do not meet inclusion criteria above.
Sites / Locations
- St. Michael's Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Multisensory Stimulation Group
Control Group
Intervention sessions will occur 3 times per week, for approximately 30 minutes per session for a total of 4 weeks. Subjects assigned to the multisensory stimulation group will receive the multisensory stimulation protocol designed for the study, which will include a variety of techniques designed to awaken the individual. Stimulus provided may include: visual activities (i.e. presenting the individual with objects/pictures to look at), auditory information (i.e. playing music or speaking), tactile stimuli (i.e. touching the individual with materials of different textures), taste and smell stimuli (i.e. offering items for the individual to taste or smell).
Intervention sessions will occur 3 times per week, for approximately 30 minutes per session for a total of 4 weeks. During each session, subjects will be played a pre-recorded reading of complex material for 30 minutes, in order to assist with control/blinding.