Program on Lung Cancer Screening and Tobacco Cessation (PLUTO)
Smoking
About this trial
This is an interventional treatment trial for Smoking focused on measuring Smoking,, Smoking cessation, Sequential, multiple assignment, randomized trials (SMART), Lung cancer screening
Eligibility Criteria
Inclusion Criteria:
- scheduled or has order for low dose CT screening for lung cancer, or is eligible for screening low-dose CT
- current daily smoker (eligible smokers will have smoked during the past 30 days and on at least 5 out of the past 7 days; individuals who have made a recent quit attempt, for example, in anticipation of their low dose CT scan for lung cancer screening, will be eligible if during the last 30 days, when they were smoking regularly, they smoked on at least 5 out of 7 days of the week).
- 55 to 79 years old,
- Interested in quitting and willing to choose a quit smoking date within the next 12 weeks,
- voluntary written consent
Exclusion Criteria:
- Unstable psychiatric disease, unless stable in treatment for 3 months (smokers on mental health medication with any changes in medication in past 3 months require study MD approval to participate) - Smokers with stable psychiatric disease will be eligible; this baseline characteristic and related symptoms will be considered in analyses,
- No hospitalization for mental health reasons in past 3 months; No thoughts of self-harm in past 2 weeks,
- No recent cognitive impairment (difficulties planning or organizing daily activities, such as managing finances, having trouble remembering appointments, or forgetting the correct month of the year); participants reporting recent cognitive impairment will be given the 6-item Callahan Cognitive Screener and must score at least a 5 out of 6 to participate,
- Participating in a formal quit program (such as tobacco cessation counseling with or without use of NRT, bupropion, or varenicline; Smokers using NRT will be eligible as long as they are not using it as part of a formal quit program),
- No phone
- Non-English speaking
- Current diagnosis of lung cancer
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
4 wk assessment + TLC monthly
4 week assessment + TLC quarterly
4 week assessment +TLC + MTM
8 week assessment + TLC monthly
8 week assessment + TLC quarterly
8 week assessment + TLC + MTM
4 week assessment, 8 weeks of counseling, NRT, monthly follow-up (responders)
4 week assessment, 8 weeks of counseling, NRT, quarterly follow-up (responders)
4 week assessment, 4 weeks counseling, NRT, medication management (nonresponders)
8 week assessment, 8 weeks of counseling, NRT, monthly follow-up (responders)
8 week assessment, 8 weeks of counseling, NRT, quarterly follow-up (responders)
8 week assessment, 8 weeks counseling, NRT, medication management (nonresponders)