Developing a COMputerised Bone Age Tool (COMBAT1)
Bone Diseases, Developmental
About this trial
This is an interventional diagnostic trial for Bone Diseases, Developmental focused on measuring Bone age, Greulich & Pyle, TW3, Radiography, Dual energy x-ray absorptiometry
Eligibility Criteria
Eligibility:
- Both female and male participants are being studied
- Minimum age 1 year
- Maximum age 15 years and 364 days
- Healthy volunteers will not be recruited
Inclusion Criteria:
- Children having a left hand radiograph performed to assess bone age on the basis of clinical need
- Children and families who have given fully informed consent/assent
- Children and families capable of reading and/or writing English
Exclusion Criteria:
1. Participants who might not adequately understand verbal explanations or written information given in English, or who have special communication needs
Sites / Locations
- Sheffield Children's NHS Foundation Trust
Arms of the Study
Arm 1
Experimental
Recruited children
Children aged below 16 years attending the Radiology Department for a left hand radiograph in order to assess bone age on the basis of clinical need. There will be one male and one female from each of five age groups (< 5 years; 5 to 7 years; 8 to 10 years; 11 to 13 years; 14 to 16 years). Bone age will be assessed according to the Greulich & Pyle and TW3 methods by 3 observers on 2 separate occasions at least 4 weeks apart. Recruited children will have intervention in the form of a left hand DXA which will be anonymised and from which the same 3 observers will independently assess bone age according to Greulich and Pyle and TW3 methods on 2 separate occasions at least 4 weeks apart. Radiographs and DXA will be read in random and varied order.