Clinical Impact of Hypothermic Machine Perfusion in Renal Transplant Recipients (CIHMP)
Delayed Function of Renal Transplant
About this trial
This is an interventional other trial for Delayed Function of Renal Transplant focused on measuring hypothermic machine perfusion, Kidney Transplantation, Delayed graft function, perfusion pressure
Eligibility Criteria
Inclusion Criteria:
Donor
- Comply with the national DCD(donor after citizen death) guideline
- No high risk activities: such as history of drug abuse, history of intravenous drug use and risky sexual behavior
- No malignant melanoma, metastatic cancer, or incurable cancer; some of the early stages of cancer after a successful treatment can also be considered
- No active, untreated systemic bacterial, viral or fungal infection;
- Patients definitely identified
- Mechanical perfusion RI (resistance index ) [0.18, 0.50]
Recipient:
- Age> = 16 years old, male or female
- BMI<28
- First Renal transplantation
- Not in pregnancy or lactation, pregnancy test was negative, and promise not to be pregnant during treatment.
- Before the clinical trial, Patient sign informed consent voluntarily
Exclusion Criteria:
Donor
- Older than 50 years old
- Serum HBV (hepatitis B virus), HCV (hepatitis C virus), HIV positive
- Donor kidney cold storage time over 30 hours
- Warm ischemia time over 20 minutes
- Other reagents are added perfusion for regulation of donor renal function
Recipient:
- Double organ or multi-organ transplant
- Blood type-incompatible
- Patients with other malignant diseases
Sites / Locations
- First Affiliated Hospital Xi'an Jiaotong UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
cold storage
Kidney Transporter machines
In this randomized clinical trial, 200 kidney pairs from deceased donors will be included in the study, which will be randomly assigned, one kidney to machine perfusion and the other to cold storage. In machine perfusion group, patients will be analyzed by two subgroups based on pressure, resistance index and perfusion time duration.
In this randomized clinical trial, 200 kidney pairs from deceased donors will be included in the study, which will be randomly assigned, one kidney to machine perfusion and the other to cold storage. In machine perfusion group, patients will be analyzed by two subgroups based on pressure, resistance index and perfusion time duration.