The Watch the Spot Trial (WTS)
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms
About this trial
This is an interventional diagnostic trial for Solitary Pulmonary Nodule
Eligibility Criteria
Inclusion Criteria:
The target population includes adults with small lung nodules that may represent a new diagnosis of lung cancer, who typically would be managed by CT surveillance in usual clinical practice. Thus, we will enroll all patients:
- aged ≥35 years
- at least one nodule measuring ≤15 mm in average diameter on chest CT.
Exclusion Criteria:
- Pregnant Women
- Age <35 years
- Known diagnosis of cancer (except non-melanoma skin cancer) within 5 years
Sites / Locations
- Kaiser Permanente Southern California
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
More Frequent CT Surveillance
Less Frequent CT Surveillance
Chest CT scans to be repeated at 3, 6, 12 and/or 24 months, depending on patient risk factors and nodule size and attenuation (density)
Chest CT scans to be repeated at 3, 6, 12 and/or 24 months, depending on patient risk factors and nodule size and attenuation (density). Overall, participants in the less frequent arm are expected to undergo 30% fewer surveillance imaging tests.