Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
Advanced Cancers, Malignant Pleural Effusions
About this trial
This is an interventional treatment trial for Advanced Cancers focused on measuring Advanced Cancers, Malignant pleural effusions, MPE, Indwelling pleural catheter, IPC, Questionnaires, Surveys, Fentanyl patch, Fentanyl by vein, Sublimaze, Doxycycline, Vibramycin, Periostat, Doryx, :Phone calls
Eligibility Criteria
Inclusion Criteria:
- Outpatients with MPE undergoing IPC placement
- Age 18 or older
- Sufficient mental capacity to answer SF-6D and Borg score questions.
Exclusion Criteria:
- Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)
- Inability or unwillingness to give informed consent
- Inability to perform phone call and clinical follow-up at MDACC
- Previous intrapleural therapy for MPE on the same side
- Chylous effusions associated with malignant disease
- ECOG of 4 and life expectancy </= 2 weeks
- Doxycycline allergy
- Contraindication to placement of an IPC (e.g., uncorrected coagulopathy)
Sites / Locations
- University of Texas MD Anderson Cancer Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Indwelling Pleural Catheter (IPC) + Saline
Indwelling Pleural Catheter (IPC) + Doxycycline
Symptom and quality of life questionnaires completed at baseline and at 10 - 14 days after receiving Saline. Participant given a Fentanyl patch which should be worn at follow up visit 5 days after IPC placement. Fentanyl patch then be removed and Fentanyl by vein given prior to catheter draining. Study staff drains the IPC and places Saline in the catheter. After the IPC is removed, participant is called one time each month by study staff to check on their status.
Symptom and quality of life questionnaires completed at baseline and at 10 - 14 days after receiving Doxycycline. Participant given a Fentanyl patch which should be worn at follow up visit 5 days after IPC placement. Fentanyl patch then be removed and Fentanyl by vein given prior to catheter draining. Study staff drains the IPC and places Doxycycline in the catheter. After the IPC is removed, participant is called one time each month by study staff to check on their status