Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU (VNI Versus)

Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU

VNI Versus is a clinical, prospective, randomized, cross over study, aiming to compare two mechanical ventilators during non-invasive ventilation for patient suffering from respiratory acidosis. This study will compare a dedicated ventilator for Non Invasive Ventilation (NIV) functioning with a turbine and with vented mask (exhalation by a calibrated leak) and a dedicated ventilator for Intensive Care Unit (ICU), functioning with non-vented masks and an exhalation valve. Patient will be randomized before the first NIV session lasting 2 hours. After a two hours wash-out, a second NIV treatment will be delivered with the other ventilator for duration of 2 hours. Arterial blood samples will be collected at the beginning and the end of each session of NIV. A transcutaneous captor of dioxide carbon pressure (PCO2) will also be used for patient monitoring.

Non-invasive ventilation, NIV ventilator, Exhalation by a calibrated leak, ICU ventilator, Respiratory acidosis, ICU

NIV with a dedicated ventilator for homecare, functioning with a turbine and with vented mask (exhalation by a calibrated leak)

Inclusion Criteria: Dioxide carbon arterial pressure > 60 mmHg Blood acidity (pH) <7.36 Exclusion Criteria:-Patient age under 18 Pregnant woman Cognitive disorder (other than the one induced by hypercapnia) Acute intoxication with morphine or benzodiazepines Patient already equipped prior to admission with a home NIV or Continuous Positive Airway Pressure (CPAP) device All contraindications to NIV already described in the French Consensus Conference on NIV, from 2006.

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