Norwegian Cartilage Project - Microfracture
Knee Injury, Cartilage Injury
About this trial
This is an interventional treatment trial for Knee Injury focused on measuring Articular cartilage, Focal cartilage injury, Focal cartilage injury in the knee, Knee cartilage, Microfracture, Debridement
Eligibility Criteria
Inclusion Criteria:
- Single symptomatic lesion of the trochlea, medial or lateral femoral condyle of the knee less than 2 cm2
- Cartilage lesion ICRS grade 3 or 4
- More than 50 % of the menisci intact
- Ligamentous stable knee
- Lysholm Score < 75
- Acceptable range of motion (5-105 degrees)
Exclusion Criteria:
- Osteoarthritis
- Malalignment > 5 degrees measured clinically, and if uncertainty on HKA radiographs
- Systemic arthritis
- Previous cartilage surgery except OCD fixation
- Obesity BMI > 30
- Serious drig or alcohol abuse
- Inability to answer questionnaires or partake in rehabilitation
- Comorbidity that may influence surgery or rehabilitation
- Pregnancy
Sites / Locations
- Akershus University Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Arthroscopic microfracture (MF)
Arthroscopic debridement (AD)
The AM group will be subjected to a diagnostic arthroscopy with a full inspection of the knee joint to ensure the inclusion criteria are fulfilled. The cartilage is cut sharp forming a rim of 90 degrees. The calcified layer is removed using a curette before an arthroscopic awl is then used to perform multiple holes ("microfractures") from the periphery towards the center. The microfractures are 3 - 4 mm apart and 2 - 4 mm deep into the subchondral bone. The correct and successful technique is confirmed by direct visualization: while reducing the fluid pump pressure, the release of marrow fat droplets and blood will be observed.
The AD group will be subjected to a diagnostic arthroscopy with a full inspection of the knee joint to ensure the inclusion criteria are fulfilled. The lesion is stabilized, debriding all loose or marginally attached cartilage from the surrounding rim to form a stable edge of healthy cartilage around the defect using a ring curette, where cartilage slops down to the defect.