The Study of Skeletal Muscle Blood Flow in Becker Muscular Dystrophy
Muscular Dystrophy
About this trial
This is an interventional basic science trial for Muscular Dystrophy focused on measuring Becker, Muscular Dystrophy, Skeletal Muscle, blood flow, Ultrasound
Eligibility Criteria
Inclusion Criteria:
- Healthy man, aged 18 to 45 years, currently taking no medication. OR
- Clinical diagnosis of Becker Muscular Dystrophy (BMD), aged 18 to 45 years, and currently taking no medication.
Exclusion Criteria:
- Hypertension, diabetes, heart failure, liver disease
- ECG evidence of prolonged QT interval
Sites / Locations
- Cedars-Sinai Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Healthy Controls (HC)
Becker Muscular Dystrophy (BMD)
Healthy men currently taking no medications will be asked to perform graded hand-grip exercise while a contrast enhanced ultrasound (CEU) probe is placed over their forearm to measure blood flow. This is repeated at baseline and shortly after taking beetroot juice extract.
currently taking no medications will be asked to perform graded hand-grip exercise while a contrast enhanced ultrasound (CEU) probe is placed over their forearm to measure blood flow. Using a lower body negative pressure (LBNP) chamber, the subjects are tested for impaired exercise induced vasodilation to the skeletal muscle or "functional sympatholysis". This is repeated at baseline and shortly after taking beetroot juice extract.