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Have a Good Grasp of the Worldthe World (GRASP)

Primary Purpose

Schizophrenic Disorders

Status

Completed

Phase

Not Applicable

Locations

France

Study Type

Interventional

Intervention

cognitive tasks + PANSS+ IQ

cognitive tasks

About this trial

This is an interventional other trial for Schizophrenic Disorders focused on measuring Schizophrenia, affordance,, perception-action binding,, stimulus-response-compatibility

Eligibility Criteria

18 Years - 55 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

For patients:
- a DSM-IV diagnosis of schizophrenia (men or women),
- no change in antipsychotic medication and clinical status within four weeks prior to the study
For patients and control group • Age ≥ 18 years et ≤ 55 years

Exclusion Criteria:

History of head trauma,
neurological disease with cerebral repercussion or not stabilized serious physical illness;
psychotropic medication
disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Exclusion Criteria:

For patients:
• IQ < 70
For patients and control group
- History of head trauma,
- neurological disease with cerebral repercussion or not stabilized serious physical illness;
- psychotropic medication
- disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Sites / Locations

Chu Saint-Etienne

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Patients

Control group

Arm Description

patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

healthy patients who will perform cognitive tasks

Outcomes

Primary Outcome Measures

response time

The gain provided by the compatible vs incompatible conditions (ms response time)

Secondary Outcome Measures

Full Information

NCT ID

NCT02655172

First Posted

January 12, 2016

Last Updated

September 5, 2019

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

1. Study Identification

Unique Protocol Identification Number

NCT02655172

Brief Title

Have a Good Grasp of the Worldthe World

Acronym

GRASP

Official Title

Study on the Links Between Action and Perception in Schizophrenia, " Have a Good Grasp of the World "

Study Type

Interventional

2. Study Status

Record Verification Date

September 2019

Overall Recruitment Status

Completed

Study Start Date

May 24, 2016 (Actual)

Primary Completion Date

April 3, 2019 (Actual)

Study Completion Date

April 3, 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Centre Hospitalier Universitaire de Saint Etienne

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible. However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and potentially associated actions (Gibson, 1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. With Tucker & Ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. In this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

Detailed Description

Schizophrenic patients will perform: Alert TEA, (Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only perform the laterality questionnaire. Then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. Participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Schizophrenic Disorders

Keywords

Schizophrenia, affordance,, perception-action binding,, stimulus-response-compatibility

7. Study Design

Primary Purpose

Other

Study Phase

Not Applicable

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

41 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Patients

Arm Type

Experimental

Arm Description

patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

Arm Title

Control group

Arm Type

Active Comparator

Arm Description

healthy patients who will perform cognitive tasks

Intervention Type

Other

Intervention Name(s)

cognitive tasks + PANSS+ IQ

Intervention Description

Patients will perform different tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield,1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale (Kay et al., 1987) + the experimental task (affordance task with graspable device)

Intervention Type

Other

Intervention Name(s)

cognitive tasks

Intervention Description

Healthy volunteers will perform only Edinburgh laterality questionnaire (Oldfield, 1971) + the experimental task (affordance task with graspable device).

Primary Outcome Measure Information:

Title

response time

Description

The gain provided by the compatible vs incompatible conditions (ms response time)

Time Frame

day 1

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

55 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: For patients: a DSM-IV diagnosis of schizophrenia (men or women), no change in antipsychotic medication and clinical status within four weeks prior to the study For patients and control group • Age ≥ 18 years et ≤ 55 years Exclusion Criteria: History of head trauma, neurological disease with cerebral repercussion or not stabilized serious physical illness; psychotropic medication disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal); Exclusion Criteria: For patients: • IQ < 70 For patients and control group History of head trauma, neurological disease with cerebral repercussion or not stabilized serious physical illness; psychotropic medication disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Anne GROSSELIN, MD

Organizational Affiliation

CHU SAINT-ETIENNE

Official's Role

Principal Investigator

Facility Information:

Facility Name

Chu Saint-Etienne

City

Saint-etienne

ZIP/Postal Code

42055

Country

France

12. IPD Sharing Statement

Plan to Share IPD

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