Accelerated Rule Out of Myocardial Infarction (AROMI)
Myocardial Infarction
About this trial
This is an interventional diagnostic trial for Myocardial Infarction focused on measuring Acute Coronary Syndrome, Prehospital emergency care, Biological markers, Copeptin, Troponin, Rule-out, Point-of-Care systems, Infarction, Cardiovascular Diseases, Heart Diseases, Ischemia, Myocardial Ischemia, copeptins, Troponin T, Diagnostic Techniques (Cardiovascular), High sensitivity troponin
Eligibility Criteria
Inclusion Criteria:
- Patients which, after telemedical triage, are admitted to a cardiac department in suspicions of myocardial infarction
- A peripheral venous catheter has been inserted prehospitally and blood has drawn from it, before flushing it.
Exclusion Criteria:
- Age below 18 years
- Patients in which an informed concent can not be obtained (psychiatric disease, dementia, under influence of drugs etc.),
- Suspected STEMI and referral to Primary percutaneous coronary intervention (PPCI), referral to a highly specialized cardiac department for another cardiac reason (e.g ventricular tachycardia, ventricular fibrillation, 3° Atrio-ventricular block.)
- Known central Diabetes insipidus
- Other diagnosis as obvious reason for symptoms at time of admittance (e.g. a new diagnosis of supraventricular tachycardia, pulmonary embolism, aortic dissection) AND no suspicions of ACS
Sites / Locations
- Department of Cardiology, Viborg Regional Hospital
- Department of Cardiology, Aarhus University Hospital
- Department of Internal Medicine, Horsens Regional Hospital
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Conventional diagnostic strategy
Accelerated diagnostic strategy
Standard Diagnostics for suspected myocardial infarction, including standard biochemical analysis: min. two measurements of high sensitive troponin T with an interval of minimum 3 hours. A normal value of high sensitive cardiac troponin-T in both blood samples rules out AMI and the patients can be discharged immediately if no other conditions are suspected.
'Accelerated, combined biomarker rule-out strategy for MI'. Copeptin measurement in a prehospital blood sample combined with high sensitive cardiac troponin T measurement in the first blood sample upon hospital admission, A normal value of both copeptin and cardiac troponin rules out AMI and the patients can be discharged immediately if no other conditions are suspected.