Stimulating Language in Subacute StrokE (SLISSE)
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring aphasia, language
Eligibility Criteria
Inclusion Criteria:
- Participant Inclusion Criteria
Participants must satisfy the following inclusion criteria to be considered eligible for entry into this study:
- Participants must have sustained an acute ischemic left hemisphere stroke.
- Participants must be fluent speakers of English by self-report.
- Participants must be capable of giving informed consent or indicating another to provide informed consent.
- Participants must be age 18 or older.
- Participants must be premorbidly right handed.
- Participants must be within 3 months of onset of stroke.
- Participants must have an aphasia diagnosis as confirmed by the Western Aphasia Battery-Revised.
- Participants must achieve at least 65% accuracy on screening task (comparable to treatment task) on 1 of 3 attempts
Exclusion Criteria:
- Participant Exclusion Criteria
Participants with any of the following characteristics will not be eligible for entry into this study:
- Previous neurological or psychiatric disease, including previous symptomatic stroke.
- Seizures during the previous 12 months.
- Uncorrected visual loss or hearing loss by self-report.
- Use of medications that lower the seizure threshold (e.g., methylphenidate, amphetamine salts).
- Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine).
- History of brain surgery or any metal in the head.
- Scalp sensitivity (per participant report).
Sites / Locations
- Johns Hopkins Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
A-tDCS & SALT
Sham-tDCS & SALT
A-tDCS (1 mA) plus Speech and Language Treatment (SALT) for 15 sessions (20-minutes per each 45-minute treatment session) over the course of 3 weeks. The electrical current will be administered to a pre-specified region of the brain. The stimulation will be delivered at an intensity of 1mA for a maximum of 20 minutes. SALT will be a computer-delivered naming + picture matching task .
Sham-tDCS plus SALT for 15 sessions (20-minutes per each 45-minute treatment session) over the course of 3 weeks. Current will be administered in a ramp-like fashion, but after the ramping, the intensity will drop to 0 mA. SALT will be a computer delivered oral naming + picture naming task.