The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery

This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)

The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level. Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.

Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program (aerobic training only)

Patients after coronary bypass surgery who undergo conventional cardiac rehabilitation program plus resistance training (aerobic and resistance training as well)

resistance training consists of lower and upper extremities exercises. We focus on biceps and hamstring to be trained. One session was held for around 30 minutes.

aerobic exercise consists of warming up session, treadmill exercise (around 20-30 minutes), and wrap-up session (for all session about 1 hour)

this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program. The method that we use to check PCSK-9 level is ELISA method

this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

Body Mass Index is calculated by calculating the measured body weight divided by the height square in measure. We take BMI data after cardiac rehabilitation program in every participant.

this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program

Blood glucose concentration was taken after 10-12-hour fasting. This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program

this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program

this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program

Inclusion Criteria: post elective coronary artery bypass surgery > 18 years old sign informed consent Exclusion Criteria: contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic > 160 mmHg diastolic > 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant) musculoskeletal pain, visual analog scale >3 post congenital heart disease surgery post elective coronary artery bypass surgery with malfunction valves (operated or not)

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informed consent, research proposal, good clinical practice certificate, World health organization quality of life questioner (in one folder)